28910-99-8

Basic information

• Product Name: NitrazolaM
• Synonyms: NitrazolaM;1-methyl-8-nitro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine;1-Methyl-8-nitro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine;1-Methyl-8-nitro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine;Nitrazolam ada@tuskwei.com whatsapp
• CAS NO: 28910-99-8
• Molecular Formula: C₁₇H₁₃N₅O₂
• Molecular Weight: 319.31742
• Product Categories: Nitrazolam ada@tuskwei.com whatsapp;8618031153937
• Mol File: 28910-99-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: NitrazolaM(CAS DataBase Reference)
• NIST Chemistry Reference: NitrazolaM(28910-99-8)
• EPA Substance Registry System: NitrazolaM(28910-99-8)

Safety Data

• Hazardous Substances Data: 28910-99-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Nitrazolam is used as a central nervous system depressant for its sedative and anxiolytic properties. It is similar to other benzodiazepines, which are commonly prescribed for the treatment of anxiety, insomnia, and other conditions related to the central nervous system.
Used in Research and Development:
Nitrazolam is used as a research compound for studying the effects of benzodiazepines on the central nervous system. Its structural similarity to other benzodiazepines makes it a valuable tool for understanding the mechanisms of action and potential risks associated with this class of drugs.
Used in Illicit Drug Market:
Unfortunately, Nitrazolam has also found its way into the novel and illicit drug markets, where it is used as a recreational substance. Its sedative and anxiolytic effects make it appealing to some users, but it also carries significant risks due to its association with adverse events and deaths.

Synthetic route

7-nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione (35628-44-5) + butan-1-ol (71-36-3) → 1-methyl-8-nitro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine (28910-99-8)

Conditions	Yield
In water

Upstream product

• 35628-44-5 7-nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione 
• 71-36-3 butan-1-ol 

Relevant articles and documents

Benzodiazepine derivatives

Benzodiazepine derivatives of the general formula STR1 where R1 is hydrogen or a hydrocarbon residue of 1-8 carbon atoms, R2 is hydrogen or lower alkyl and rings A and B are unsubstituted or substituted by nitro, trifluoromethyl, halogen, lower alkyl or lower alkoxy, the nitrogen atom in the 5-position being unsubstituted or substituted by an oxygen atom, useful as muscle relaxants, anticonvulsants, sedatives and tranquilizing agents, and processes for production thereof. Also provided are novel intermediates of the general formula STR2 where R2 has the above meaning, rings A and B are unsubstituted or substituted as above and the nitrogen atom in the 4-position is unsubstituted or substituted by an oxygen atom.

6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines

6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines of the formula (IV): SPC1 wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms, inclusive, phenyl, benzyl and -COOR' in which R' is alkyl of 1 to 4 carbon atoms, inclusive; wherein R1 is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, inclusive; and wherein R2, R3, R4 and R5 are selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms, inclusive, halogen, nitro, cyano, trifluoromethyl, and alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoylamino and dialkylamino in which the carbon chain moieties are of 1 to 3 carbon atoms, inclusive, are produced by condensing a 1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione of the formula (I): SPC2 wherein R1, R2, R3, R4 and R5 are defined as above, with an organic acid hydrazide of the formula: EQU1 wherein R is defined as above. The new products of formula IV including their pharmacologically acceptable acid addition salts are useful as sedatives, tranquilizers and muscle relaxants in mammals and birds.

Animal feed and process

An animal feed comprising a compound of the group consisting of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines of the formula: STR1 WHEREIN R is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms, inclusive, phenyl, benzyl and -COOR' in which R' is alkyl of 1 to 4 carbon atoms, inclusive; wherein R1 is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, inclusive; and wherein R2, R3, R4 and R5 are selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms, inclusive, halogen, nitro, cyano, trifluoromethyl, and alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoylamino and dialkylamino in which the carbon chain moieties are of 1 to 3 carbon atom, inclusive and their pharmacologically acceptable acid addition salts in combination with a nutrient feed. A process for obtaining increased productivity in meat producing, milk producing, and egg laying animals by feeding the aforementioned compounds in combination with nutrient feeds.