289896-68-0Relevant articles and documents
Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics
Aujay, Monette,Das, Dipendu,Gavrilyuk, Julia,Hammond, Mikhail,Lu, Yong,Lyssikatos, Joseph,Nicolaou, K. C.,Pitsinos, Emmanuel N.,Rout, Subhrajit,Sandoval, Joseph,Schammel, Alexander
supporting information, (2020/02/13)
The family of anthraquinone-fused enediyne antitumor antibiotics was established by the discovery of dynemicin A and deoxy-dynemicin A. It was then expanded, first by the isolation of uncialamycin, and then by the addition to the family of tiancimycins A-
Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives as potential antitumor candidate
Zhu, Panhu,Ye, Wenfeng,Li, Jiaming,Zhang, Yanchun,Huang, Weijun,Cheng, Mohan,Wang, Yujun,Zhang, Yang,Liu, Huicai,Zuo, Jian
, p. 443 - 455 (2017/04/03)
A novel class of tetrahydroisoquinoline derivatives was designed and synthesized as antitumor agents and evaluated for their in vitro and in vivo biological activities. The antiproliferative activities of all the target compounds on HUVEC, MCF-7, and HT-2
Synthesis of aryl-substituted naphthalene-linked pyrrolobenzodiazepine conjugates as potential anticancer agents with apoptosis-inducing ability
Kamal, Ahmed,Reddy, M. Kashi,Ramaiah, M. Janaki,Srikanth,Rajender,Reddy, V. Santosh,Kumar, G. Bharath,Pushpavalli,Bag, Indira,Juvekar, Aarti,Sen, Subrata,Zingde, Surekha M.,Pal-Bhadra, Manika
experimental part, p. 1665 - 1679 (2012/01/05)
A library of new aryl-substituted naphthalene C8-linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates with various linker architectures were designed, synthesized, and evaluated for their anticancer activity against a panel of 11 human cancer cell lines. All 32 conjugates show anticancer potential, with some of them exhibiting particularly high activity (0.01-0.19μM). Thermal denaturation studies showed effective DNA binding capacity relative to DC-81. In assays for biological activity relating to cell-cycle distribution, these PBD conjugates induce G0/G1-phase arrest and also cause an increase in the levels of p53 and caspase-9 proteins, followed by apoptotic cell death. One conjugate in particular is the most promising candidate of the series, with the potential to be selected for further studies, either alone or in combination with existing anticancer therapies. Getting into the groove: Pyrrolobenzodiazepine (PBD) conjugates showed an effective ability to bind DNA. They induce G0/G1-phase arrest, enhance the expression levels of p53 and caspase-9, and induce apoptosis. One conjugate stands out as particularly promising; it is a suitable candidate for further study, either alone or in combination with current anticancer therapies.
NO-mediated aromatic nitration during decomposition of phenolic S-nitrosothiols in non-aqueous aerobic medium
Petit,Bernardes-Genisson,Hoffmann,Souchard,Labidalle
, p. 1634 - 1638 (2007/10/03)
Five novel S-nitrosothiol compounds (6-10) derived from L-cysteine were generated in solution and their decomposition rate was followed by UV spectroscopy. In acetonitrile, compounds 9 and 10 were the most stable of this series with a half-life of 24 h. T