One-Pot Assembly of 3-Hydroxycarbazoles via Uninterrupted Propargylation/Hydroxylative Benzannulation Reactions
A novel strategy for the synthesis of 3-hydroxycarbazoles involving the consecutive propargylation/palladium-catalyzed hydroxylative benzannulation of indole-2-carbonyls with propargylic alcohols has been exploited. This one-pot procedure leads to a wide range of substituted 3-hydroxycarbazoles in high yield with a broad substrate scope. The method was further extended to access furano-carbazole derivatives from dialkynols via tandem annulations.
Synthesis of highly substituted indene derivatives by Br?nsted acid catalyzed Friedel-Crafts reaction of homoallylic alcohols
An efficient synthetic method to prepare highly substituted indenes in moderate to excellent yields that relies on Br?nsted acid catalyzed Friedel-Crafts reaction of homoallylic alcohols under mild conditions is described.
Zhang, Xiaoxiang,Teo, Wan Teng,Rao, Weidong,Ma, Dik-Lung,Leung, Chung-Hang,Chan, Philip Wai Hong
supporting information
p. 3881 - 3884
(2014/07/08)
Di- and triheteroarylalkanes via self-condensation and intramolecular Friedel-Crafts type reaction of heteroaryl alcohols
An efficient synthetic approach to diheteroarylmethanes and 1,3-diheteroarylpropenes has been developed via Yb(iii)-catalyzed sequential self-condensation of 2-furfuryl (or 2-thienyl or 3-indolyl) alcohols followed by intramolecular Friedel-Crafts type re
Dhiman, Seema,Ramasastry
supporting information
p. 8030 - 8035
(2013/12/04)
Indolecarbonyl Coupling Reactions Promoted by Samarium Diiodide. Application to the Synthesis of Indole-Fused Compounds
By the assistance of an N-sulfonyl group or a cyano group at the C-2 position, hydroxyalkylations of indole-3-carbonyls were achieved by the promotion of samarium diiodide. The indolecarbonyl coupling reactions proceeded in high stereoselectivity via chel