Synthesis of 2-Arylpyrazolo[1,5- a ]pyridines by Suzuki-Miyaura Cross-Coupling Reaction
Convenient access to a variety of 2-arylated pyrazolo[1,5-a]pyridine via pyrazolo[1,5-a]pyridine-2-yl triflate using the Suzuki-MiyauraA AA cross-coupling reaction is described. Fifteen 2-arylpyrazolo[1,5-a]pyridine derivatives were synthesized in 52-95% yields.
The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitors
A series of pyrazolo[1,5-a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described.
Cheung, Mui,Harris, Philip A.,Badiang, Jennifer G.,Peckham, Gregory E.,Chamberlain, Stanley D.,Alberti, Michael J.,Jung, David K.,Harris, Stephanie S.,Bramson, Neal H.,Epperly, Andrea H.,Stimpson, Stephen A.,Peel, Michael R.
scheme or table
p. 5428 - 5430
(2009/06/18)
Fused pyrazole derivatives bieng protein kinase inhibitors
Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R1, (R2, and R4 are various substituent groups, are protein kinase inhibitors.
-
(2008/06/13)
Pyrazolopyridines
The invention provides the compounds of formula (I) wherein: R0and R1are independently selected from H, halogen, C1-6alkyl, C1-6alkoxy, or C1-6alkoxy substituted by one or more fluorine atoms; R2
-
(2008/06/13)
More Articles about upstream products of 291744-01-9