- Synthesis of hydrohalocyclobutenes through dechlorination of hydrohalocyclobutanes in amide solvents
-
In this study, we synthesized hydrohalocyclobutenes through the dechlorination of hydrohalocyclobutanes in N,N-dimethylformamide and N,N-dimethylacetamide. The structure of the reaction site ?CClR1?CClR2– (R1 = H, F; R2 = H, F, Cl) of the reactants was critical for the efficient reductive dechlorination from the 1- and 2- positions. The reaction proceeded efficiently at the –CFCl–CFCl–, –CFCl?CCl2–, and ?CHCl?CHCl– groups. Conversely, the –CFCl?CHCl– group could hardly afford the dechlorinated product. Based on these results, we propose a rational reaction mechanism.
- Guo, Qin,Lu, Fengniu,Quan, Hengdao,Zhang, Chengping,Zhang, Wenni
-
-