- Synthesis of 4,4′-Bis[4-(2,5-dioxo-2,5-dihydro-1H-pyrroll-1-yl)-phenylcarbonylamino]-3,3′-dichlorodiphenylmethane and 1,4-Bis{2-[4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-phenylcarbonyloxy]ethoxy}benzene
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4,4′-Bis[4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenylcarbonylamino]-3,3′-dichlorodiphenylme-thane has been obtained by the reaction of 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoyl chloride with 4,4′-diamino-3,3′-dichlorodiphenylmethane. 1,4-Bis[2-(4-
- Kolymshin,Danilov,Ignatev,Kuzmin
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- Thermal degradation kinetics and thermodynamics of maleimide-sytrene based alternating copolymer: A comparative investigation of monomer and polymer structures
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Thermal degradation of N-(4-(3-Thienyl methylene)-oxycarbonylphenyl) maleimide monomer, MT and its copolymer with styrene, P(MT-alt-St) were investigated comparatively using TG and DTA methods. Degradation of monomer takes place in three stages which correspond to removal of thiophene, aliphatic groups and the rest of structural decomposition respectively. Degradation of the copolymer occurs in two stages. Thiophene and aliphatic groups decompose simultaneously at the first degradation stage. The main polymeric chain remains intact. The second stage is related to the rest of structural decomposition. Activation energy values of these reactions were calculated by using Flynn-Wall-Ozawa (FWO) and Kissinger-Akahira-Sunose (KAS) methods. In order to determine the effective reaction model and calculate thermodynamic parameters, these methods were combined with modeling equations. It was found that the first degradation stages of monomer and copolymer show good harmony with diffusion model (D1), whereas nucleation and growth model (A2) is effective for the second decomposition stage of the monomer.
- Ak, Metin,Koyundereli ??lg?, Gülbanu
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- Preparation and characterization of new carrier drug polymers based maleimide and its drug release behaviour
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In this work, two new drug substituted monomers and new homogenous and heterogeneous polymers were synthesized loaded with medicinal properties to extend the controlled drug. The first step includes preparation of compound (F1) via reaction of maleic anhydride with 4-aminobenzoic acid. Then compound (F1) was converted to its corresponding acyl chloride derivative which reacted with amino drugs (sulfadiazine, chlordiazepoxide) afforded (F2 and F3) monomers. Homogeneous polymers (F8 and F9) prepared through polymerization reaction of free radicals of the monomers (F2 and F3) under nitrogen using methyl ethyl ketone peroxide (MEKP) as initiator. Heterogeneous polymers (F14 and F15) prepared through polymerization reaction of free radicals of the monomers (F2 and F3) separately with acrylic acid under nitrogen using methyl ethyl ketone peroxide (MEKP) as initiator. All these prepared monomers and polymers were characterized by FT-IR and 1H NMR, 13C NMR spectroscopies. Controlled drug release and swelling % was studied in different pH values at 37 oC. Intrinsic viscosities were measured at 25 oC with Ostwald viscometer and applied the characteristic of solubility for these polymers.
- Mageed, Fatimah Abdul Razzak,Kareem, Mohanad Musa,Al-Baiati, Mohammad N.
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p. 569 - 574
(2019/02/06)
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- Thermosetting compounds
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Provided is a thermosetting compound that has satisfactory solvent solubility and can be rapidly cured by a heat treatment to form a cured product having extreme heat resistance. The thermosetting compound according to the present invention is represented
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Paragraph 0125; 0131-0135; 0144
(2019/03/12)
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- Synthesis and evaluation of a novel fluorescent chemosensor for glutathione based on a rhodamine B and N-[4-(carbonyl) phenyl]maleimide conjugate and its application in living cell imaging
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A novel rhodamine B spirolactam derivative bearing an N-[4-(carbonyl)phenyl] maleimide moiety (L1) was designed, synthesized and structurally characterized to develop a chemosensor. The interactions of L1 with amino acids and metal ions were studied by UV–vis absorption and fluorescence spectroscopy. L1 exhibited a highly sensitive and selective turn-on fluorescence response toward glutathione (GSH) over other biological species in EtOH/HEPES (3:2, v/v, 0.1?mM, pH 7.34) solution. The detection limit of GSH by L1 was 0.219?μM. Intracellular imaging applications demonstrated that L1 can be used as a fluorescent probe for the detection of GSH in HepG-2 and HUVEC cells.
- Shu, Hai,Wu, Xiaolei,Zhou, Baojing,Han, Yingbin,Jin, Mingjie,Zhu, Jing,Bao, Xiaofeng
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p. 535 - 542
(2016/09/19)
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- Maleimide copolymers containing azobenzene moieties-synthesis and study of liquid crystalline and optical properties
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New reactive copolymers have been synthesized by copolymerization of two functional N-substituted-maleimides with styrene. These copolymers, with aldehyde and carboxyl functional groups, were further chemically modified with p-aminoazobenzene. After verification of the chemical structures by IR and 1H-NMR spectroscopy, the copolymers were characterized by solubility, X-ray diffraction measurements and their thermal stability was controlled by thermogravimetrical analysis (TGA). The thermal and thermotropic properties were investigated using polarizing optical microscopy (POM) and differential scanning calorimetry (DSC). A comparative study of the photoisomerization in solution and thermal recovery characteristics of azo copolymers vs. the corresponding maleimide model compound has been performed.
- Cozan, Vasile,Hulubei, Camelia,Airinei, Anton,Morariu, Simona
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p. 101900 - 101910
(2016/11/09)
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- Novel antimicrobial organic thermal stabilizer and co-stabilizer for rigid PVC
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Biologically active N-benzoyl-4-(N-maleimido)-phenylhydrazide (BMPH) was synthesized and its structure was confirmed by elemental analysis and various spectral tools. It was examined as a thermal stabilizer and co-stabilizer for rigid poly (vinyl chloride) at 180°C in air. Blending BMPH with reference samples in different ratios greatly lengthens the thermal stability value and improves the extent of discoloration of PVC. TGA confirmed the improved stability of PVC in presence of the investigated organic stabilizer. GPC measurements were done to investigate the changes occurred in the molecular masses of the degraded samples of blank PVC and PVC in presence of the novel stabilizer. BMPH showed good antimicrobial activity towards two kinds of bacteria and two kinds of fungi.
- Fahmy, Mona M.,Mohamed, Riham R.,Mohamed, Nadia A.
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experimental part
p. 7927 - 7940
(2012/10/08)
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- Bismaleimide monomers with various structures and polyaspartimides
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A series of bismaleimide monomers with various structures were synthesized by the reaction of bisphenols or diamines with 3 or 4- maleimidobenzoyl chloride. The reaction of these bismaleimides with aromatic diamines (Michael addition) yielded polyaspartimides. The monomers and polymers were characterized by FTIR and 'H-NMR spectroscopy and elemental analysis. Thermal characterization of monomers and polymers was accomplished by differential scanning calorimetry and dynamic thermogravimetric analysis. Some of the mechanical properties of the films based on these polymers were studied.
- Sava, Mitica
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p. 929 - 937
(2013/09/23)
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- The synthesis and characterisation of reactive poly(p-phenylene terephthalamide)s: A route towards compression stable aramid fibres
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Herein we report on the synthesis of reactive poly(p-phenylene terephthalamide) (PPTA) oligomers and the preparation and characterisation of aramid fibres thereof. Methacrylate and maleimide reactive end-groups were found to be sufficiently stable in H2SO4 at 85?°C and they were used to prepare reactive PPTA oligomers. Lyotropic spin-dopes could be prepared with up to 20?wt% of reactive oligomer (Mn?=?3900?g?mol-1) and this modification did not interfere with the fibre spinning process and had no effect on the fibre tensile properties. The as-spun fibres did indeed show a modest (+0.1?GPa) improvement in compression strength. A high temperature treatment at 380?°C resulted in fibres which all show a significant increase in compressive strength over their as-spun precursors, i.e. from 0.7 to 0.9?GPa. When fibres were treated at 430?°C the compression values of the oligomer-modified fibres dropped somewhat, whereas unmodified PPTA displayed a compressive strength of 1.1?GPa. Other favourable fibre properties such as modulus and tenacity were not compromised.
- Knijnenberg, Alwin,Bos, Johan,Dingemans, Theo J.
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scheme or table
p. 1887 - 1897
(2011/11/14)
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- Functional maleimide-based structural polymers
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Two reactive imide type polymers, polymaleimides and addition polyimides have been prepared. Polymaleimides based on N-(4-carboxy-phenyl)maleimide have been synthesized by free radical polymerization, thus resulting the corresponding homopolymer, a linear copolymer with N-vinyl-2-pyrrolidone, and a cross-linked (co)polymer in reaction with trimethylolpropane trimethacrylate. Addition polyimides based on N, N'-4, 4'-diphenylether- bismaleimide have been obtained by Michael polyaddition of 5-amino-salicylic acid and 5, 5-methylene-bissalicylic acid to the bismaleimide double bond. The chemical structures were identified by IR, and 10H-NMR spectroscopy. The calculated Q1 and e1 parameters for N-(4-carboxy-phenyl) maleimide in copolymerization with N-vinyl-2-pyrrolidone are of 0.035 and 1.013, respectively. The resulting bead-like (co)polymers have porous structures and a diameter in the range of 0.1-1.0 mm. Addition polyimides present inherent viscosities in the 0.28-0.37 dL/g range, and decomposition temperatures above 290 °C.
- Hulubei, Camelia
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experimental part
p. 743 - 752
(2009/12/24)
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- Synthesis and characterisation of peripherally functionalised dendritic molecules
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A number of peripherally functionalised dendritic molecules were synthesised in almost quantitative yield by a synthetic method involving the reaction between amines and isocyanates. The peripheral functional groups were incorporated by preparing a number
- Atkinson, Sarah J.,Ellis, Vicky-June,Boyd, Sue E.,Brown, Christopher L.
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p. 155 - 162
(2007/10/03)
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- Hemoglobin-superoxide dismutase-chemical linkages that create a dual-function protein
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Chemical reagents were designed to cross-link and connect hemoglobin and superoxide dismutase, combining the oxygen transport and superoxide-removal capabilities of the red cell in a dual-function protein. Reaction of 1 with thiol-protected hemoglobin followed by reduction produces cross-linked hemoglobin with a free thiol on the cross-link. Reaction of SOD with 5 produces a cross-linked protein with a maleimide on the cross-link. Addition of the hemoglobin-thiol to the SOD-maleimide produces a protein with the desired dual properties. Hemoglobin's oxygenation cooperativity is lowered as a result of being in the conjugate, while SOD's activity is equal to that of the native protein.
- Alagic, Amer,Koprianiuk, Agnieszka,Kluger, Ronald
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p. 8036 - 8043
(2007/10/03)
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- Ab-monomers. I: Synthesis and polymerization of furyl-maleimide monomers
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New AB-monomers containing either furyl and maleimide groups or hydroxy and acid groups were prepared by the reaction of 4-maleimidobenzoic acid chloride or 4-maleimidophenylisocyanate with 2-furfuryl alcohol or the Diels-Alder reaction of 4-maleimidobenzoic acid with 2-furfuryl alcohol, respectively. The structures of the monomers were confirmed by IR, 1H-NMR and elemental analysis. By Diels-Alder polymerization reaction or polycondensation reaction new poly(esther-imide) or poly(urethane-imide)s were prepared. Thermal curing behavior of monomers was investigated by DSC analysis. All polymers were characterized by elemental analysis, IR spectral studies and thermogravimetry.
- Gǎinǎ, Viorica,Gǎinǎ, Constantin
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p. 881 - 890
(2007/10/03)
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- Synthesis and characterization of α,ω-bis(maleimide-ester) and α,ω-BIS(maleimide-amide) substituted polysiloxanes
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Organofunctional polysiloxanes containing end aromatic ester or amide groups were synthesized by the hydrosilation of ring substituted styrene with hydrogen terminated polydimethylsiloxane (HPDMS) followed by chemical transformation of the resulting products. End phenylmaleimide groups were attached to the siloxane chains by coupling of -Ar-OH or -Ar-NH2 functionalized polysiloxanes with N-(p-carboxyphenyl)maleimide chloride. The structures of intermediate and final compounds were confirmed by IR and 1H-NMR spectroscopy and the thermal behavior was evidenced by DSC.
- Cernenco, Undina,Pintealǎ, Mariana,Harabagiu, Valeria,Sava, Miticǎ,Simionescu, Bogdan C.
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p. 257 - 262
(2007/10/03)
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- Thermal studies of bismaleimides. II Bismaleimides with ester units
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Bismaleimides containing ester groups in the backbone were synthesized from 3(4)-maleimido benzoic acid chloride with varies diphenols. These bismaleimides are characterized by DSC studies, thermogravimetric analysis and isothermal gravimetric analysis (IGA). The thermal properties of these compounds were compared.
- Sava, Miticǎ,Gǎinǎ, Constantin,Gǎinǎ, Viorica
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p. 1167 - 1173
(2007/10/03)
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- Compounds with electron donor and electron acceptor functionality
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Compounds containing both electron donor and electron acceptor functionality are suitable for use in adhesives. The electron donor group is a carbon to carbon double bond attached to an aromatic ring and conjugated with the unsaturation in the ring. The electron acceptor group is a maleimide, acrylate, fumarate or maleate.
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- Synthesis of novel thiol-reactive amphiphilic lipids based on cholesterol for protein-liposome coupling
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The synthesis of a series of coupling lipids designed for covalently linking proteins to liposomes is described. The new compounds have in common a cholesterylsuccinyl unit as a lipid anchor and a thiol-reactive maleimidobenzoyl unit which are linked by alkyl or (poly)ethylene glycol spacers that differ in length and polarity.
- Kley, Joerg T.,Fichert, Thomas,Massing, Ulrich
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p. 319 - 327
(2007/10/03)
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