- Method for preparing N -benzylhydroxylamine hydrochloride with high yield
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The invention discloses a method for preparing N - benzylhydroxylamine hydrochloride in a high yield, which comprises the following steps: S01, taking dibenzylamine as a starting raw material, adding a solvent, a catalyst and dropwise adding first oxidant
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Paragraph 0076; 0078; 0083-0086
(2021/08/25)
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- Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides
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Selective C-H amidation of 1H-indoles at the C3 position is reported as a direct entry to biologically important 3-aminoindoles. This transformation is achieved using novel N-[(benzenesulfonyl)oxy]amides as electrophilic nitrogen agents in the presence of ZnCl2. Interestingly, analogous reactions in the absence of ZnCl2 resulted in the formation of indole aminal products.
- Ortiz, Gerardo X.,Hemric, Brett N.,Wang, Qiu
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supporting information
p. 1314 - 1317
(2017/03/23)
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- Profiling base excision repair glycosylases with synthesized transition state analogs
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Two base excision repair glycosylase (BER) transition state (TS) mimics, (3R,4R)-1-benzyl (hydroxymethyl) pyrrolidin-3-ol (1NBn) and (3R,4R)- (hydroxymethyl) pyrrolidin-3-ol (1N), were synthesized using an improved method. Several BER glycosylases that repair oxidized DNA bases, bacterial formamidopyrimdine glycosylase (Fpg), human OG glycosylase (hOGG1) and human Nei-like glycosylase 1 (hNEIL1) exhibit exceptionally high affinity (K d～pM) with DNA duplexes containing the 1NBn and 1N nucleotide. Notably, comparison of the Kd values of both TS mimics relative to an abasic analog (THF) in duplex contexts paired opposite C or A suggest that these DNA repair enzymes use distinctly different mechanisms for damaged base recognition and catalysis despite having overlapping substrate specificities.
- Chu, Aurea M.,Fettinger, James C.,David, Sheila S.
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supporting information; experimental part
p. 4969 - 4972
(2011/10/09)
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- A large-scale low-cost preparation of n-benzylhydroxylamine hydrochloride
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A high-yielding, practical two-step procedure for the preparation of N-benzylhydroxylamine starting from dibenzylamine is described. As specified in the detailed protocol, the reaction can be conveniently carried out on a > 0.5 mol laboratory scale.
- Nguyen, Thanh Binh,Martel, Arnaud,Dhal, Robert,Dujardin, Gilles
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experimental part
p. 3174 - 3176
(2009/12/29)
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- One-pot synthesis and hydroxylaminolysis of asymmetrical acyclic nitrones
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Aromatic aldehydes 1 were reductively aminated to the corresponding secondary amines 2 using NaBH4 in methanol in good yields. Amines 2 were oxidized with H2O2-WO42- regioselectively to nitrones 3, the structures of which were easily determined by reacting them with hydroxylamine hydrochloride as well as by spectral means. The products of hydroxylaminolysis in ether proved to be the corresponding benzaldehyde oximes 4 and benzyl or methyl hydroxylamine hydrochlorides 5. Copyright Taylor & Francis, Inc.
- Coskun, Necdet,Parlar, Aydin
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p. 2445 - 2451
(2007/10/03)
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- Reaction of Sydnones with Oxygen
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The reaction of 3-benzyl- and 3-(p-chlorobenzyl)-4-phenylsydnones (1a and 1b) and of 3-benzylsydnone (1c) with oxygen at room temperature in the dark is described.Possible rationalizations for the formation of the products obtained are suggested.
- Nakajima, Masayuki,Anselme, Jean-Pierre
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p. 1444 - 1448
(2007/10/02)
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