- KCNT1 INHIBITORS AND METHODS OF USE
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The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.
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Paragraph 000271
(2020/11/23)
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- A two-fluoro the benzyl is wicked zole miticides (by machine translation)
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The invention provides a two-fluoro the benzyl is wicked zole compound, structure such as shown in formula I: In the formula: R1 Is selected from methyl or ethyl; R2 Is selected from methyl, ethyl or tertiary butyl; R3 Selected from H or Cl. The formula I compound to the insects, mites of killing effect, can be regarded as insecticide, acaricide for pests in agriculture, digestion control. (by machine translation)
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Paragraph 0017; 0024; 0025; 0026
(2019/02/25)
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- 3-(2,6-difluorophenyl)-1,2,4-oxadiazole compound and application thereof
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The invention provides a 3-(2,6-difluorophenyl)-1,2,4-oxadiazole compound insecticide/acaricide with a structure as shown in a general formula I in the specification, wherein R is as shown in the specification. The compound as shown in the general formula
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Paragraph 0028-0031
(2019/02/25)
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- Synthesis, insecticidal activity, and structure-activity relationship (SAR) of anthranilic diamides analogs containing oxadiazole rings
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A series of anthranilic diamides analogs (3-11, 16-24) containing 1,2,4- or 1,3,4-oxadiazole rings were synthesized and characterized by 1H NMR, MS and elemental analyses. The structure of 3-bromo-N-(2-(3-(4-bromophenyl)-1, 2,4-oxadiazol-5-yl)-
- Li, Yuhao,Zhu, Hongjun,Chen, Kai,Liu, Rui,Khallaf, Abdalla,Zhang, Xiangning,Ni, Jueping
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supporting information
p. 3979 - 3988
(2013/07/05)
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- TRIAZOLE OXADIAZOLES DERIVATIVES
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The invention relates to compounds of formula (I), wherein R1, R2, Ra, Rb, X have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
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Page/Page column 98
(2009/07/25)
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