297171-80-3

Basic information

• Product Name: 4-(4-Methyl-4H-1,2,4-triazol-3-yl)piperidine hydrochloride
• Synonyms: 4-(4-Methyl-4H-1,2,4-triazol-3-yl)piperidine hydrochloride;Piperidine, 4-(4-Methyl-4H-1,2,4-triazol-3-yl)-, hydrochloride (1:1)
• CAS NO: 297171-80-3
• Molecular Formula: C8H14N4.HCl
• Molecular Weight: 202.69
• EINECS: 604-604-1
• Mol File: 297171-80-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-(4-Methyl-4H-1,2,4-triazol-3-yl)piperidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Methyl-4H-1,2,4-triazol-3-yl)piperidine hydrochloride(297171-80-3)
• EPA Substance Registry System: 4-(4-Methyl-4H-1,2,4-triazol-3-yl)piperidine hydrochloride(297171-80-3)

Safety Data

• Hazardous Substances Data: 297171-80-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
4-(4-Methyl-4H-1,2,4-triazol-3-yl)piperidine hydrochloride is used as a heterocyclic building block for the synthesis of pharmaceuticals, due to its unique structure that can be incorporated into more complex molecules.
Used in Chemical Research:
4-(4-Methyl-4H-1,2,4-triazol-3-yl)piperidine hydrochloride is used as a research compound in the field of chemistry, where its properties and reactivity can be studied and utilized in the development of new chemical processes and products.
Used in Laboratory Procedures:
4-(4-Methyl-4H-1,2,4-triazol-3-yl)piperidine hydrochloride is used as a reagent in various laboratory procedures, benefiting from its improved solubility as a hydrochloride salt, which facilitates its use in polar solvents and reaction systems.

Upstream product

• 187834-88-4 tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate 

Relevant articles and documents

NOVEL INHIBITORS

The invention relates to a compound of formula (I): A-B-D-E (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein: A is selected from monocyclic and bicyclic heteroaryl, which may independently substituted by alkyl or amino; B is selected from alkyl, heteroalkyl, alkyl-amino, aryl, heteroaryl, cycloalkyl, heterocyclyl and alkylene, wherein said groups may independently be substituted by alkyl; D is selected from aryl-amino, heteroaryl-amino, cycloalkyl-amino, heterocyclyl, heterocyclyl-amino, urea, thioamide, thiourea, sulfonamide, sulfoximine and sulfamoyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups may independently be substituted; and E is selected from aryl, heteroaryl, cycloalkyl, heterocyclyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups may independently be substituted. The compounds of formula (I) are inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N- terminal glutamate residues into pyroglutamic acid under liberation of water.