- Hydrogen Atom Transfer-Mediated Cyclisations of Nitriles
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Hydrogen atom transfer-mediated intramolecular C?C coupling reactions between alkenes and nitriles, using PhSiH3 and catalytic Fe(acac)3, are described. This introduces a new strategic bond disconnection for ring-closing reactions, f
- Turner, Oliver J.,Murphy, John A.,Hirst, David J.,Talbot, Eric P. A.
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supporting information
p. 18658 - 18662
(2018/11/23)
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- Synthesis of benzocyclic ketones via palladium-catalyzed cyclization of ω-(2-iodoaryl)alkanenitriles
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An efficient procedure for the synthesis of 2,2-disubstituted benzocyclic ketones by intramolecular carbopalladation of nitriles has been developed. The cyclization of substituted 3-(2-iodoaryl)propanenitriles affords indanones in high yields. The reactio
- Pletnev, Alexandre A.,Larock, Richard C.
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p. 2133 - 2136
(2007/10/03)
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- Carbopalladation of nitriles: Synthesis of benzocyclic ketones and cyclopentenones via Pd-catalyzed cyclization of ω-(2-iodoaryl)alkanenitriles and related compounds
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An efficient procedure for the synthesis of 2,2-disubstituted benzocyclic ketones by intramolecular carbopalladation of nitriles has been developed. The cyclization of substituted 3-(2-iodoaryl)-propanenitriles affords indanones in high yields. The reaction is compatible with a wide variety of functional groups. This methodology has been extended to the synthesis of tetralones and cyclopentenones.
- Pletnev, Alexandre A.,Larock, Richard C.
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p. 9428 - 9438
(2007/10/03)
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- Rate enhancement with high ratio of the monoalkylated product to the dialkylated product in the alkylation of the lithium enolate of 1-tetralone with reactive alkyl halides
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The reactions of the lithium enolate of 1-tetralone with reactive alkyl halides were examined in the absence and in the presence of 3 eq of various ligands for the lithium. It is shown that the rates of the reactions are enhanced greatly in the presence a tetradentate amine (1,1,4,7,10,10-hexamethyltriethylenetetramine), and the ratio of the monoalkylated product to the dialkylated product is increased under shorter reaction times.
- Goto,Akimoto,Aoki,Shindo,Koga
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p. 1529 - 1531
(2007/10/03)
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- 1,1,4,7,10,10-Hexamethyltriethylenetetramine: A reagent to enhance the rate of alkylation reaction of the lithium enolate of 1-tetralone with alkyl halides
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The rate of the reaction of the lithium enolate of 1-tetralone with alkyl halides was enhanced greatly in the presence of 3 equivalents of 1,1,4,7,10,10-hexamethyltriethylenetetramine. The ratio of the monoalkylated product to the dialkylated product was found to have increased under a shorter reaction time.
- Goto, Mariko,Akimoto, Koh-ichi,Aoki, Kazumasa,Shindo, Mitsuru,Koga, Kenji
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p. 8129 - 8132
(2007/10/03)
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