- Preparation method for propyzamide
-
The invention discloses a preparation method for propyzamide. The preparation method comprises the following steps: preparing 3-chloro-3-methylbutyne through a chlorination reaction; then preparing 3-amino-3-methylbutyne through an aminolysis reaction; and then carrying out an amidation reaction so as to prepare high-purity propyzamide. The optimal preparation method for propyzamide is screened out through a large number of experiments; the preparation method is reasonable in the whole process design and simple and efficient in process operation; in particular, optimal reaction conditions arescreened out, optimal raw material composition is determined for the chlorination reaction in the step 1, the aminolysis reaction in the step 2 and the amidation reaction in the step 3, and the proportions of reaction raw materials, reaction temperature, reaction time and the like are optimized, so reaction yield can be greatly increased (wherein the yield can reach 93% or more), side reactions can be reduced, reaction rate can be increased, and production cost can be greatly lowered; so the preparation method has good application prospects.
- -
-
Paragraph 0009-0010; 0041-0043; 0049
(2018/05/01)
-
- A method for preparing alkyne benzoyl grass amine (by machine translation)
-
The present invention provides a method for preparing alkyne benzoyl grass amine, comprising a condensation step: by parts by mass to 3 - amino - 3 - methyl [...] 100 - 105 parts, triethylamine 2 - 5 parts and solvent 100 - 500 parts into 10% -32% ω of sodium hydroxide solution 200 - 400 parts by, after stir, dropping 3, 5 - dichloro benzoyl chloride 100 - 105 parts, temperature control in 12 - 15 °C, after dropping, thermal insulation 1 - 5 hours. The alkyne benzoyl grass amine preparation method of the advantage of high purity of the product. (by machine translation)
- -
-
Paragraph 0023
(2018/04/01)
-
- Cu(I)-catalyzed synthesis of dihydropyrimidin-4-ones toward the preparation of β- And β3-amino acid analogues
-
A copper(I)-catalyzed synthesis of substituted dihydropyrimidin-4-ones from propargyl amides via the formation of ketenimine intermediate has been successfully developed; the synthesis afforded good isolated yields (80-95%). The mild reaction conditions at room temperature allow the reaction to proceed to completion in a few hours without altering the stereochemistry. Further, by involving a variety of reactive nucleophiles, the obtained substituted dihydropyrimidin-4-ones were elegantly transformed into the corresponding β- and β3-amino acid analogues.
- Rajagopal, Basker,Chen, Ying-Yu,Chen, Chun-Chi,Liu, Xuan-Yu,Wang, Huei-Ren,Lin, Po-Chiao
-
supporting information
p. 1254 - 1264
(2014/03/21)
-
- REACTIONS OF NITROGEN NUCLEOPHILES WITH 1-BROMOALLENES: REGIOSELECTIVE SYNTHESIS OF PROPARGYLAMINES
-
The results of a study on the reactivity of 3-alkyl- and 3,3-dialkyl-1-bromo-1,2-dienes 2 towards nitrogen nucleophiles, such as aqueous ammonia, lithium amide, aliphatic and aromatic amines allowed us to propose new methods for the synthesis of propargylamines, 1, with an available acetylenic hydrogen.The regio- and the stereoselectivity of these reactions are examined and possible mechanisms are discussed.
- Geri, Roberto,Polizzi, Carmela,Lardicci, Luciano,Caporusso, Anna Maria
-
p. 241 - 248
(2007/10/02)
-
- Preparation of a Series of Highly Hindered Secondary Amines, Including Bis(triethylcarbinyl)amine
-
A series of highly branched secondary amines was prepared by coupling propargylamines with propargyl chlorides.Hydrogenation of the resultant dipropargylamines was accomplished with Raney nickel in the presence of potassium hydroxide.The resultant amines, including bis(triethylcarbinyl)amine, are among the most hindered secondary amines reported to date.The pKa values of the conjugate acids of the series of secondary amines exhibit a regular decrease with increasing size of the amine.The bulkier members of the series are inert to methyl iodide.Bis(triethylcarbinyl)amine reacts with boron trifluoride etherate to give a primary amine adduct and 3-ethyl-2-pentene.
- Kopka, Ihor E.,Fataftah, Zacharia A.,Rathke, Michael W.
-
p. 4616 - 4622
(2007/10/02)
-
- S-aryl N-alkynylthiolcarbamates
-
Novel S-aryl N-alkynylthiolcarbamates such as S-4-methoxyphenyl N-(1,1-dimethyl-2-propynyl)thiolcarbamate which are useful for controlling the effect on plants of plant pests such as pathogenic nematodes, fungi, or other pathogenic organisms; particularly Meloidogyne nematodes, Sclerotium rolfsii, Fusarium solani, and Puccinia rubigo-vera are disclosed. The methods of controlling plant pests with these thiolcarbamates are also disclosed.
- -
-
-