Samarium-Promoted Cyclopropanation of Allylic Alcohols
The use of samarium/mercury amalgam in conjunction with diiodomethane or chloroiodomethane to generate samarium carbenoids for the efficient cyclopropanation of allylic alcohols is discussed.These hydroxyl-directed cyclopropanations occur under mild conditions and allow a wide range of substitution about both the olefin and the carbinol carbon in allylic alcohol substrates.High yields and high diastereoselectivities are observed for many substrates.
Molander, Gary A.,Harring, Lori S.
p. 3525 - 3532
(2007/10/02)
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