Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3
A series of 2-acylaminothiophene-3-carboxamides has been identified which exhibit potent inhibitory activity against the FLT3 tyrosine kinase. Compound 44 inhibits the isolated enzyme (IC50 = 0.027 μM) and blocks the proliferation of MV4-11 cel
Patch, Raymond J.,Baumann, Christian A.,Liu, Jian,Gibbs, Alan C.,Ott, Heidi,Lattanze, Jennifer,Player, Mark R.