298688-65-0Relevant articles and documents
Synthesis of N-substituted (3S,4S)- and (3R,4R)-pyrrolidine-3,4-diols: Search for new glycosidase inhibitors
Lysek, Robert,Vogel, Pierre
, p. 3167 - 3181 (2007/10/03)
N-Substituted (3S,4S)- and (3R,4R)-pyrrolidine-3,4-diols 9 and 10, respectively, were derived from (+)-L-and (-)-D-tartaric acid, respectively. Compounds 9k, 91, and 9m with the N-substituents, BnNH(CH2) 2, 4-PhC6H4/
Polyhydroxypyrrolidine glycosidase inhibitors related to (+)-lentiginosine1
Cardona, Francesca,Goti, Andrea,Picasso, Sylviane,Vogel, Pierre,Brandi, Alberto
, p. 585 - 601 (2007/10/03)
(+)-Lentiginosine (14) and (7R)-7-hydroxylentiginosine (26), powerful inhibitors of amyloglucosidases, and their enantiomers were obtained in high overall yields by a multistep synthesis involving 1,3-dipolar cycloaddition of enantiopure tartaric acid derived pyrroline N-oxides. Structurally related (S,S)-3,4-dihydroxypyrrolidines 29-33 were synthesized as simpler models and tested towards 24 glycosidases.