298700-56-8

Basic information

• Product Name: (-)-EGCG-3'-O-ME
• Synonyms: (-)-EPIGALLOCATECHIN-3'-O-METHYL ETHER GALLATE;(-)-EGCG-3'-O-ME;(-)-Epigallocatechin-3'-O-methylether Gallate 〔(-)-EGCg-3'-O-Me〕
• CAS NO: 298700-56-8
• Molecular Formula: C23H20O11
• Molecular Weight: 472.4
• Mol File: 298700-56-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (-)-EGCG-3'-O-ME(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-EGCG-3'-O-ME(298700-56-8)
• EPA Substance Registry System: (-)-EGCG-3'-O-ME(298700-56-8)

Safety Data

• Hazardous Substances Data: 298700-56-8(Hazardous Substances Data)

Usage

Uses

Used in Functional Foods:
(-)-EGCG-3'-O-ME is used as a functional ingredient for its potential antioxidant, anti-inflammatory, and anti-cancer properties, as well as its neuroprotective effects.
Used in Dietary Supplements:
(-)-EGCG-3'-O-ME is used as a dietary supplement to support cardiovascular health and aid in the prevention of neurodegenerative diseases and metabolic disorders.
Used in Pharmaceuticals:
(-)-EGCG-3'-O-ME is used as a therapeutic compound for its potential health benefits, including its antioxidant, anti-inflammatory, and anti-cancer properties, as well as its neuroprotective effects and potential role in preventing neurodegenerative diseases and improving cardiovascular health and metabolic disorders.

Upstream product

• 1186527-34-3 (2R,3R)-2-(3-methoxy-4,5-bis(2-nitrophenylsulfonyloxy)phenyl)-5,7-bis(2-nitrophenylsulfonyloxy)-chroman-3-yl 3,4,5-tris(2-nitrophenylsulfonyloxy)benzoate 
• 1186527-17-2 3,4,5-tri(2-nitrobenzenesulfonyloxy)benzoic acid 
• 1186527-18-3 (2R,3R)-2-(3-methoxy-4,5-bis(2-nitrophenylsulfonyloxy)phenyl)-3-hydroxy-3,4-dihydrochroman-5,7-diyl bis(2-nitrobenzenesulfonate) 

Relevant articles and documents

Syntheses of methylated catechins and theaflavins using 2-nitrobenzenesulfonyl group to protect and deactivate phenol

An efficient and versatile synthetic method for labile polyphenols was established using 2-nitrobenzenesulfonate (Ns) as a protecting group for phenol. This methodology provides regio-and stereoselective access to a range of methylated catechins, such as methylated epigallocatechin gallates, that are not readily available from natural sources. In addition, biomimetic synthesis of theaflavins from catechins was accomplished using Ns protection to minimize undesired side reactions of electron-rich aromatic rings during oxidation, enabling construction of the complex benzotropolone core in a single-step oxidative coupling reaction. Availability of these compounds will aid detailed structure-biological activity relationship studies of catechins.

Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group

Regioselective synthesis of methylated epigallocatechin gallate from epigallocatechin was accomplished using a 2-nitrobenzenesulfonyl (Ns) group as a protecting group for phenols. This methodology provided several methylated catechins, which are naturally