- Synthesis and Biological Evaluation of Cyanogenic Glycosides
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An efficient procedure for the synthesis of cyanogenic glycosides with different carbohydrate units was developed. Amygdalin (3), prunasin (1), sambunigrin (2), and neoamygdalin (21) were prepared according to the elaborated method, and biological tests, including antifungal, antibacterial, and cytotoxic activities, were performed.
- Yashunsky, Dmitry V.,Kulakovskaya, Ekaterina V.,Kulakovskaya, Tatiana V.,Zhukova, Olga S.,Kiselevskiy, Mikhail V.,Nifantiev, Nikolay E.
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p. 460 - 474
(2015/12/23)
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- Aromatic glucosides from the seeds of Prunus davidiana
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Chemical investigation of the seeds of Prunus davidiana afforded seven new aromatic glucosides, i.e., the prupersins A-E (1-5) and compounds 6 and 7, as well as 11 known compounds. The structures of 1-7 were elucidated by spectroscopic data analysis and chemical evidence, and configurations were determined by hydrolysis experiments (1, 2, and 5) or electronic circular dichroism (6). Compounds 1-6 exhibited antioxidant activity aganist Fe 2+-cysteine-induced rat liver microsomal lipid peroxidation, with malondialdehyde inhibitory rates of 50-67% and 53-57% at concentrations of 10-5 and 10-6 mol/L, respectively.
- Chen, Xiao-Yan,Wang, Hong-Qing,Zhang, Ting,Liu, Chao,Kang, Jie,Chen, Ruo-Yun,Yu, De-Quan
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p. 1528 - 1534
(2013/10/22)
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- Study on the Prevention of Racemization of Amygdalin
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Studies were conducted to find suitable conditions for the prevention of racemization of amygdalin in aqueous solution.Evaluation of racemization was carried out by determination of the ratios of neoamygdalyn and amygdalin using a capillary gas chromatographic technique.Racemization of amygdalin in aqueous solution was accelerated by increases on pH and temperature, but racemization was low below pH 3.0 even with heating.Ascorbic acid is useful as an acidification reagent for the suppression of racemization, and has the added clinical benefit of vitamin C activity.Keywords - amygdalin; isoamygdalin separation; racemization; racemizati on prevention; capillary gas chromatography
- Takayama, Yuzi,Kawai, Satoshi
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p. 778 - 781
(2007/10/02)
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