Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity
Three different histaminergic H1 scaffolds were attached by various linkers to a single 5-LO scaffold. Both activities were observed in vitro. Pharmacokinetic properties of the compounds were evaluated and both a cetirizine-based compound and a
Lewis, Timothy A.,Young, Michelle A.,Arrington, Mark P.,Bayless, Lynn,Cai, Xiong,Collart, Philippe,Eckman, Joseph B.,Ellis, James L.,Ene, Doina G.,Libertine, Lyn,Nicolas, Jean-Marie,Scannell, Ralph T.,Wels, Bruce F.,Wenberg, Karen,Wypij, Donna M.
p. 5591 - 5594
(2007/10/03)
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