Directed Functionalization of Cyano-Substituted Furans and Thiophenes with TMPMgCl·LiCl
A number of novel difunctionalized furans and thiophenes has been prepared by the reaction of the cyano-substituted substrates with TMPMgCl·LiCl followed by the reaction with electrophiles. The crucial metalation step takes place under mild conditions allowing the isolation of desired derivatives in reasonable to good yields.
Dos Santos, Fernanda M.,Batista, Jo?o H. C.,Vessecchi, Ricardo,Clososki, Giuliano C.