300542-58-9

Basic information

• Product Name: 17-O-Trimethylsilyl 6,7-Dehydro Norethindrone
• Synonyms: 17-O-Trimethylsilyl 6,7-Dehydro Norethindrone;(17α)-17-[(TriMethylsilyl)oxy]-19-norpregna-4,6-dien-20-yn-3-one
• CAS NO: 300542-58-9
• Molecular Formula: C23H32O2Si
• Molecular Weight: 368.58448
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 300542-58-9.mol

Chemical Properties

• Boiling Point: 451.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.07±0.1 g/cm3(Predicted)
• Solubility: Tetrahydrofuran
• CAS DataBase Reference: 17-O-Trimethylsilyl 6,7-Dehydro Norethindrone(CAS DataBase Reference)
• NIST Chemistry Reference: 17-O-Trimethylsilyl 6,7-Dehydro Norethindrone(300542-58-9)
• EPA Substance Registry System: 17-O-Trimethylsilyl 6,7-Dehydro Norethindrone(300542-58-9)

Safety Data

• Hazardous Substances Data: 300542-58-9(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Relevant articles and documents

14(15)-unsaturated 15- and/or 16-substituted androgens with mixed androgen-progrestational profile

Disclosed are androgen-related steroids having a Δ14 double bond and carrying a substituent at either or both of the carbon atoms nos. 15 and 16. The present steroids are characterized by possessing a mixed profile of androgenic and progestagenic activities. This makes these compounds suitable for male or female hormone replacement therapy, as well as male contraception.

Novel androgens

The disclosed invention relates to the unexpected finding of novel steroids which are characterized by a 14β,15β-cyclopropane ring and a 17α hydroxymethyl group. These steroids according to the invention are found to have in common an androgenic activity.

ORALLY ACTIVE 7-ALPHA-ALKYL ANDROGENS

Orally Active androgens are derivative of 7alpha-methyl-19-nortestosterone. The compounds satisfy formula (I) wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6) alkyl, or (C1-6) acyl; R2 is ethyl optionally substituted by halogen; R3 is hydrogen, (C1-2) alkyl, or ethenyl; R4 is (C1-2) alkyl; R5 is hydrogen, or (C1-15)acyl; and the dotted lines indicate optional bonds.

Orally active androgens

Novel, orally active androgens are 7α-substituted Δ14-nandrolone derivatives. The compounds satisfy the general formula: wherein R1is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6) alkyl, or (C1-6) acyl; R2is selected from the group consisting of (C2-4) alkyl, (C2-4) alkenyl, or (C2-4) alkynyl, each optionally substituted by halogen; or R2is cyclopropyl, or cyclopropenyl, each optionally substituted by (C1-2) alkyl, or halogen; R3is hydrogen, (C1-2) alkyl, or ethenyl; R4is (C1-2) alkyl; R5is hydrogen, or (C1-15) acyl; and the dotted lines indicate optional bonds.