Straightforward Access to the Nitric Oxide Donor Azasydnone Scaffold by Cascade Reactions of Amines
A novel one-pot cascade method for the assembly of valuable NO-donor azasydnone scaffold has been developed. The construction strategy involves a diazotization/azo coupling/elimination/double rearrangement cascade sequence of readily available amines. The
Zhilin, Egor S.,Bystrov, Dmitry M.,Ananyev, Ivan V.,Fershtat, Leonid L.,Makhova, Nina N.
p. 14284 - 14289
(2019/11/11)
N -Oxide-Controlled Chemoselective Reduction of Nitrofuroxans
A facile and chemoselective SnCl 2 -mediated mild reduction of regioisomeric 3- and 4-nitrofuroxans for the synthesis of aminofurazans and aminofuroxans in good yields is developed. Reduction of 4-nitrofuroxans results in the selective formation of 4-aminofuroxans, while analogous reduction of 3-nitrofuroxans affords 3-aminofurazans as a result of simultaneous reduction of the nitro group and exocyclic N-O bond.
Fershtat, Leonid L.,Bystrov, Dmitry M.,Zhilin, Egor S.,Makhova, Nina N.
p. 747 - 756
(2019/01/23)
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