Synthesis of substituted N-hydroxyureas via the in situ generation of t-butoxy isocyanate
Treatment of primary and secondary amines with tert- butylmesitylenesulfonoxycarbamate and a base afforded tert-butoxyurea, which when treated with an acid ultimately yielded substituted N-hydroxyureas. It is proposed that this proceeded via the generation of t-butoxy isocyanate in situ. This method allows for the synthesis of both mono and disubstituted N-hydroxyureas.
Krause, Josef G.,Leskiw, Brian D.,Emery, Michelle L.,McGahan, Megan E.,McCourt, Mary P.,Priefer, Ronny
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p. 3568 - 3570
(2010/08/07)
α-Haloalkyl Haloformates and Related Compounds 3.1 A Facile Synthesis of Symmetrical and Unsymmetrical Ureas via Chloromethyl Carbamates
Chloromethyl carbamates were prepared by the reaction of chloromethyl chloroformates with amines and found to produce mono-, symmetrically or unsymmetrically di- and trisubstituted ureas including their N-hydroxy and N-alkoxy derivatives in moderate to good yield.
Patonay, Tamas,Patonay-Peli, Erzsebet,Zolnai, Laszlo,Mogyorodi, Ferenc
p. 4253 - 4265
(2007/10/03)
REACTION OF TRISUBSTITUTED UREAS WITH AMINO-CONTAINING COMPOUNDS
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Veis, I.,Ruff, E.,Otvosh, L.
p. 694 - 696
(2007/10/02)
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