Synthesis of Biginelli compounds using cobalt hydrogen sulfate
Efficient synthesis of various 2-oxo(thioxo)-1,2,3,4-tetrahydropyrimidines containing acetyl, carboethoxy, carbomethoxy and carboxamide groups on 5-position of the M-substituted and ATL-unsubstituted heterocyclic ring was achieved using cobalt hydrogen su
Memarian, Hamid Reza,Ranjbar, Mahnaz
experimental part
p. 522 - 527
(2012/01/05)
Synthesis and biological evaluation of novel homocamptothecins conjugating with dihydropyrimidine derivatives as potent topoisomerase i inhibitors
Homocamptothecin (hCPT) is a camptothecin (CPT) homologue with the insertion of a methylene (-CH2-) spacer between the alcohol moiety and carbonyl group of the classical six-membered α-hydroxylactone ring. This modification provides higher lact
A convenient one-pot Biginelli reaction catalyzed by Y(OAc)3: An improved protocol for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and their sulfur analogues
Yttrium(III) acetate hydrate-catalyzed novel synthesis of 3,4-dihydropyrimidin-2(1H)-(thio)one derivatives was achieved through one-pot three-component condensation of diversified aldehydes, β-ketoesters and urea or N-methylurea or thiourea with a molar r
Aridoss, Gopalakrishnan,Jeong, Yeon Tae
experimental part
p. 863 - 868
(2010/10/19)
Dowex-promoted general synthesis of N,N′-disubstituted-4-aryl-3,4-dihydropyrimidinones using a solvent-free Biginelli condensation protocol
Dowex-50W ion exchange resin-promoted solvent-free heating of an intimate mixture of an aldehyde, an active methylene compound and N,N′-dimethylurea furnished the title compounds in moderate to good yields.
Singh, Kamaljit,Arora, Divya,Singh, Sukhdeep
p. 4205 - 4207
(2007/10/03)
Expedient Synthesis of Biginelli-Type Dihydropyrimidinones Using α-(Benzotriazolyl)alkyl Urea Derivatives
Reaction of readily available α-(benzotriazolyl)alkyl urea derivatives (derived from aromatic, heteroaromatic, and aliphatic aldehydes) with β-keto esters resulted in 3,4-dihydropyrimidin-2(1H)-ones in good to excellent yields.
Abdel-Fattah, Ashraf A. A.
p. 2358 - 2362
(2007/10/03)
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