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5-Methoxy-4-methylindole, also known as 5-methoxy-4-methyl-1H-indole, is a substituted 1H-indole with potential applications in various chemical and pharmaceutical processes. It has been evaluated for its efficacy as a substrate for indigoid production.

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  • 302912-21-6 Structure
  • Basic information

    1. Product Name: 5-METHOXY-4-METHYLINDOLE
    2. Synonyms: 5-METHOXY-4-METHYLINDOLE;5-Methoxy-4-Methyl-1H-indole;1H-Indole, 5-Methoxy-4-Methyl-;5-Methoxy-4-Methylindole 98%;4-Methyl-5-methoxyindole
    3. CAS NO:302912-21-6
    4. Molecular Formula: C10H11NO
    5. Molecular Weight: 161.2
    6. EINECS: N/A
    7. Product Categories: Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Indoles
    8. Mol File: 302912-21-6.mol
  • Chemical Properties

    1. Melting Point: 76-79 °C(lit.)
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-METHOXY-4-METHYLINDOLE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-METHOXY-4-METHYLINDOLE(302912-21-6)
    11. EPA Substance Registry System: 5-METHOXY-4-METHYLINDOLE(302912-21-6)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26-36
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 302912-21-6(Hazardous Substances Data)

302912-21-6 Usage

Uses

Used in Pharmaceutical Industry:
5-Methoxy-4-methylindole is used as a reactant for the preparation of β-carboline-1-carboxylic acids, which serve as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MAPK-activated protein kinase 2). This application is significant in the development of treatments for various diseases and conditions involving abnormal cell signaling.
5-Methoxy-4-methylindole is also used as a reactant for the preparation of indolyl and isoquinolinyl anthranilates, which act as PPARδ (peroxisome proliferator-activated receptor delta) partial agonists. These compounds have potential applications in the treatment of metabolic disorders, such as diabetes and obesity, by modulating the activity of PPARδ.
In Chemical Industry:
5-Methoxy-4-methylindole is utilized as a substrate for the synthesis of various indigoid compounds, which are important in the production of dyes and pigments. Its efficacy in this process has been evaluated, making it a valuable component in the chemical industry for the development of new and improved products.

Check Digit Verification of cas no

The CAS Registry Mumber 302912-21-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,2,9,1 and 2 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 302912-21:
(8*3)+(7*0)+(6*2)+(5*9)+(4*1)+(3*2)+(2*2)+(1*1)=96
96 % 10 = 6
So 302912-21-6 is a valid CAS Registry Number.

302912-21-6 Well-known Company Product Price

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  • Aldrich

  • (497231)  5-Methoxy-4-methylindole  98%

  • 302912-21-6

  • 497231-1G

  • 1,990.17CNY

  • Detail

302912-21-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-methoxy-4-methyl-1H-indole

1.2 Other means of identification

Product number -
Other names 1H-Indole,5-methoxy-4-methyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:302912-21-6 SDS

302912-21-6Downstream Products

302912-21-6Relevant articles and documents

Therapeutic diphenyl ether ligands

-

Page/Page column 35, (2010/10/20)

This invention is directed to compounds of formula Ia, Ib or Ic and to pharmaceutical compositions thereof: or a prodrug thereof and a pharmaceutically acceptable carrier, wherein the R groups are defined in the specification; and, in which the dashed line represents an optional double bond. The invention is also directed to methods of treating, diagnosing, and preventing disorders of the central nervous system that are associated with 5HT receptors, including obesity, attention deficit disorder, migraine, depression, epilepsy, anxiety, Alzheimer's disease, withdrawal from drug abuse, pain, schizophrenia, stress-related disorders, panic disorder, sleep disorders, phobias, obsessive compulsive disorder, post-traumatic-stress syndrome, immune system depression, stress-induced gastrointestinal dysfunction, stress-induced cardiovascular dysfunction, and sexual dysfunction.

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