The development and preparation of the 2,4-dimethoxybenzyl arylhydrazine (DMBAH) "latent" safety-catch linker: solid phase synthesis of ketopiperazines.
The development and preparation of the 2,4-dimethoxybenzyl arylhydrazine (DMBAH) linker 3, a new class of "latent" safety-catch linker which is stable under Mitsunobu alkylation conditions and in the presence of amines and hydrazine, is reported. The util
Berst, Frederic,Holmes, Andrew B,Ladlow, Mark
p. 1711 - 1719
(2007/10/03)
A latent aryl hydrazine 'safety-catch' linker compatible with N-alkylation
The preparation and use of a latent aryl hydrazine 'safety-catch' linker for solid-phase chemistry, which is compatible with N-alkylation, is reported. Its use is exemplified by the preparation of mono-ketopiperazines, whereby release from resin is effect
Berst,Holmes,Ladlow,Murray
p. 6649 - 6653
(2007/10/03)
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