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303144-44-7

1-(2-Pyrimidinyl)piperidine-4-carboxylic acid is a chemical compound that belongs to the class of organic compounds known as piperidinecarboxylic acids. These are compounds containing a piperidine ring which bears a carboxylic acid group. The molecular structure consists of a piperidine-4-carboxylic acid nucleus which bears a pyrimidine group at the 1-position. The detailed study of the properties, pharmaceutical uses, or synthetic processes of this compound is not largely documented in the scientific literature. Therefore, its physical properties, safety hazards, biological roles, or uses, if any, are not well known. As such, it's always recommended to handle it with adequate safety and precautionary measures until comprehensive data are available.

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  • 303144-44-7 Structure

  • Basic information

    1. Product Name: 1-(2-Pyrimidinyl)piperidine-4-carboxylic acid
    2. Synonyms: 1-(2-Pyrimidyl)piperidine-4-carboxylic acid;1-Pyrimidin-2-yl-piperidine-4-carboxylicacid95%;1-PYRIMIDIN-2-YL-PIPERIDINE-4-CARBOXYLIC ACID 95%;1-(2-Pyrimidinyl)piperidine-4-carboxylic acid;AKOS BBS-00001573;1-(2-PYRIMIDINYL)-4-PIPERIDINECARBOXYLIC ACID;1-PYRIMIDIN-2-YL-PIPERIDINE-4-CARBOXYLIC ACID;BUTTPARK 90\06-41
    3. CAS NO:303144-44-7
    4. Molecular Formula: C10H13N3O2
    5. Molecular Weight: 207.23
    6. EINECS: N/A
    7. Product Categories: Carboxylic Acids;Pyrans, Piperidines &Piperazines;Carboxylic Acids;Pyrans, Piperidines & Piperazines
    8. Mol File: 303144-44-7.mol

  • Chemical Properties

    1. Melting Point: 103-105°C
    2. Boiling Point: 434 °C at 760 mmHg
    3. Flash Point: 216.2 °C
    4. Appearance: /
    5. Density: 1.291 g/cm3
    6. Vapor Pressure: 2.67E-08mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. PKA: 4.16±0.20(Predicted)
    11. CAS DataBase Reference: 1-(2-Pyrimidinyl)piperidine-4-carboxylic acid(CAS DataBase Reference)
    12. NIST Chemistry Reference: 1-(2-Pyrimidinyl)piperidine-4-carboxylic acid(303144-44-7)
    13. EPA Substance Registry System: 1-(2-Pyrimidinyl)piperidine-4-carboxylic acid(303144-44-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 303144-44-7(Hazardous Substances Data)

303144-44-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 303144-44-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,3,1,4 and 4 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 303144-44:
(8*3)+(7*0)+(6*3)+(5*1)+(4*4)+(3*4)+(2*4)+(1*4)=87
87 % 10 = 7
So 303144-44-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H13N3O2/c14-9(15)8-2-6-13(7-3-8)10-11-4-1-5-12-10/h1,4-5,8H,2-3,6-7H2,(H,14,15)/p-1

303144-44-7 Well-known Company Product Price

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  • Alfa Aesar

  • (H50351)  1-(2-Pyrimidinyl)piperidine-4-carboxylic acid, 95%   

  • 303144-44-7

  • 250mg

  • 501.0CNY

  • Detail

  • Alfa Aesar

  • (H50351)  1-(2-Pyrimidinyl)piperidine-4-carboxylic acid, 95%   

  • 303144-44-7

  • 1g

  • 1798.0CNY

  • Detail

303144-44-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-pyrimidin-2-ylpiperidine-4-carboxylic acid

1.2 Other means of identification

Product number -
Other names 1-(2-Pyrimidinyl)Piperidine-4-Carboxylic Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:303144-44-7 SDS

303144-44-7Downstream Products

303144-44-7Relevant articles and documents

Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity

De Candia, Modesto,Fiorella, Filomena,Lopopolo, Gianfranco,Carotti, Andrea,Romano, Maria Rosaria,Lograno, Marcello Diego,Martel, Sophie,Carrupt, Pierre-Alain,Belviso, Benny D.,Caliandro, Rocco,Altomare, Cosimo

, p. 8696 - 8711 (2013/12/04)

The design and synthesis of a new class of nonpeptide direct thrombin inhibitors, built on the structure of 1-(pyridin-4-yl)piperidine-4-carboxamide, are described. Starting from a strongly basic 1-amidinopiperidine derivative (6) showing poor thrombin (fIIa) and factor Xa (fXa) inhibition activities, anti-fIIa activity and artificial membrane permeability were considerably improved by optimizing the basic P1 and the X-substituted phenyl P4 binding moieties. Structure-activity relationship studies, usefully complemented with molecular modeling results, led us to identify compound 13b, which showed excellent fIIa inhibition (Ki = 6 nM), weak anti-Xa activity (K i = 5.64 μM), and remarkable selectivity over other serine proteases (e.g., trypsin). Compound 13b showed in vitro anticoagulant activity in the low micromolar range and significant membrane permeability. In mice (ex vivo), 13b demonstrated anticoagulant effects at 2 h after oral dosing (100 mg·kg-1), with a significant 43% prolongation of the activated partial thromboplastin time (aPTT), over controls (P 0.05).

1, 4-DISUBSTITUTED PIPERIDINES AS VASOPRESSIN RECEPTOR VIA ANTAGONISTS

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Page/Page column 43-44, (2010/09/17)

The present invention provides compounds of formula (1) compositions comprising such compounds; the use of such compounds in therapy (such as in the treatment of dysmenorrhoea); and methods of treating patients with such compounds; wherein A and G are as defined herein.

PIPERIDINE/CYCLOHEXANE CARBOXAMIDE DERIVATIVES FOR USE AS VANILLOID RECEPTOR MODULATORS

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Page/Page column 13, (2010/02/10)

Certain compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, P, P', X, m and n are as defined in the specification, a process for preparing such compounds, a pharmaceutical composition c

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