3034-47-7

Basic information

• Product Name: 2-CHLORO-5-NITROTHIAZOLE
• Synonyms: 2-CHLORO-5-NITROTHIAZOLE;2-Cholro-5-nitrothiazole;2-chloro-5-nitro-1,3-thiazole
• CAS NO: 3034-47-7
• Molecular Formula: C₃HClN₂O₂S
• Molecular Weight: 164.57024
• Mol File: 3034-47-7.mol

Chemical Properties

• Melting Point: 61℃
• Boiling Point: 305.288 °C at 760 mmHg
• Flash Point: 138.433 °C
• Appearance: /
• Density: 1.715
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.84±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-NITROTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-NITROTHIAZOLE(3034-47-7)
• EPA Substance Registry System: 2-CHLORO-5-NITROTHIAZOLE(3034-47-7)

Safety Data

• Hazardous Substances Data: 3034-47-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-5-nitrothiazole is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of various medicinal compounds. Its unique structure allows for the creation of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-5-nitrothiazole serves as an intermediate in the production of agrochemicals, aiding in the development of pesticides and other agricultural chemicals that are essential for crop protection and enhancement of yield.
Used as a Reagent:
2-Chloro-5-nitrothiazole is utilized as a reagent for selective modification of aromatic and heterocyclic amines, playing a crucial role in organic synthesis and the preparation of specialized chemical compounds for various applications.

InChI:InChI=1/C3HClN2O2S/c4-3-5-1-2(9-3)6(7)8/h1H

Upstream product

• 121-66-4 2-amino-5-nitro-1,3-thiazole 

Downstream Products

• 21166-11-0 cyclohexyl-(5-nitro-thiazol-2-yl)-amine 
• 61126-48-5 5-nitro-2-[4-(2-nitro-vinyl)-phenoxy]-thiazole 

Relevant articles and documents

ORGANIC SYNTHESIS USING ORGANOSULFUR-NITRITES AND -NITRATES

Thionitrites or thionitrates have been considered to be unstable.However, bulky groups' thio-NOn such as t-butylthio-nitrites and -nitrates have been readily synthesized and found to be stable enough for the use of the useful organic syntheses as an excellent nitrosation and diazotization reagents under mild conditions.Direct conversion of amines to the corresponding halides in the presence of copper halides (II), fluorination of heterocyclic amines in the presence of sodium tetrafluoroborate, α- oximation of methylene groups in ketones, facile cleavage of C=N bond to ketones, and desulfurization of thioacetals and thioketals, and other useful organic syntheses are described.