Reactions of imidazopyridine, pyrimidine and pyrazine (1)-(3) with formaldehyde or acetaldehyde give the corresponding alcohols and secondary products characterized by 1H and 13C n.m.r.X-Ray crystallographic analysis confirms the structure of (6).The two-step sequence of n-butyllithium and reaction with aldehydes with (2)-(3) does not lead to the alcohols but to n-butyl derivatives with substituents at C(7) and C(8) respectively.
Teulade, Jean C.,Bonnet, Pierre A.,Rieu, Jean N.,Viols, Henry,Chapat, Jean P.,et al.
p. 1842 - 1874
(2007/10/02)
Novel Condensation of 2,3-Epoxybutanal with 2-Aminopyridine and 2-Aminopyrazine. Synthesis and Stability of 3-(1-Hydroxyethyl)imidazoazines
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Lumma, William C.,Springer, James P.
p. 3735 - 3736
(2007/10/02)
Imidazole derivatives. IV. Synthesis and pharmacologic activity of oxygenated derivatives of imidazo(1,2-a)pyridine.
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Almirante,Mugnaini,De Toma,Gamba,Murmann
p. 1048 - 1051
(2007/10/04)
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