305796-69-4

Basic information

• Product Name: Hydrazinecarboxylic acid, 2-(1-oxo-2-propynyl)-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Hydrazinecarboxylic acid, 2-(1-oxo-2-propynyl)-, 1,1-dimethylethyl ester (9CI)
• CAS NO: 305796-69-4
• Molecular Formula: C8H12N2O3
• Molecular Weight: 184.19248
• Product Categories: N-BOC
• Mol File: 305796-69-4.mol

Chemical Properties

• Appearance: /
• Density: 1.132±0.06 g/cm3(Predicted)
• PKA: 8.56±0.43(Predicted)
• CAS DataBase Reference: Hydrazinecarboxylic acid, 2-(1-oxo-2-propynyl)-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarboxylic acid, 2-(1-oxo-2-propynyl)-, 1,1-dimethylethyl ester (9CI)(305796-69-4)
• EPA Substance Registry System: Hydrazinecarboxylic acid, 2-(1-oxo-2-propynyl)-, 1,1-dimethylethyl ester (9CI)(305796-69-4)

Safety Data

• Hazardous Substances Data: 305796-69-4(Hazardous Substances Data)

Upstream product

• 870-46-2 t-butoxycarbonylhydrazine 
• 471-25-0 Propiolic acid 

Relevant articles and documents

A CONJUGATE OF AN AMANITA TOXIN WITH BRANCHED LINKERS

Provided herein is the conjugation of an amanita toxin compound to a cell-binding molecule with branched linkers for having better targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of an amanita molecule to a cell-binding ligand, as well as methods of using the conjugate in targets treatment of cancer, infection and autoimmune disease.

A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS

The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS

The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LIKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS

The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.