- Gelation properties of various long chain amidoamines: Prediction of solvent gelation via machine learning using Hansen solubility parameters
-
Four new amphiphilic long chain amidoamine derivatives displaying different structure variations are synthesized and tested in 27 liquids and compared to the study of two similar molecules already reported in the literature. In many cases, these compounds can act as low molecular weight gelators to form a three-dimensional network in organic liquids or water, which can be confirmed by FE-SEM observations and rheology measurements. For each sample, XRD diffraction of the corresponding xerogel and FT-IR analysis of native supramolecular gels reveal that they can self-assemble into lamellar-like aggregates or in pseudo-cubic structures, depending on the alkyl chain length and the steric hindrance of the polar head. The number of amide bonds and their positions inside gelator structures are determinant for the nature of the packing. For each gelator, we perform a series of gelation tests in each of the solvents and show that Hansen parameters, which are known characteristics of each liquid, can be used to successfully predict their gelation properties via machine learning in the vast majority of liquids at a concentration of 4 wt%.
- Adenier, Guillaume,Delbecq, Frederic,Kawai, Takeshi,Ogue, Yuki
-
-
- Method and apparatus for manufacturing carboxylic acid amide compound
-
The present invention relates to a process and an apparatus for producing a carboxylic acid amide compound, and more particularly, to a process for producing a carboxylic acid amide compound which alternately performs a reaction process of a first manufacturing process that promotes the reaction between a first carboxylic acid and a first ammonia in the presence of a first catalyst and a reaction process of a second manufacturing process that promotes the reaction between a second carboxylic acid and a first ammonia in the presence of a second catalyst wherein each of them is progressed alternately between each preparation process so that the reaction between the carboxylic acid and the ammonia, which is intermittently carried out by the respective preparation processes, can be continuously performed, and moreover, the time required for the respective preparation processes is shortened, so that the carboxylic acid amide compound can be produced in a large amount in a short time.
- -
-
Paragraph 0059-0062; 0076
(2017/06/02)
-
- Electrospray ionization and collision induced dissociation mass spectrometry of primary fatty acid amides
-
Primary fatty acid amides are a group of bioactive lipids that have been linked with a variety of biological processes such as sleep regulation and modulation of monoaminergic systems. As novel forms of these molecules continue to be discovered, more emphasis will be placed on selective, trace detection. Currently, there is no published experimental determination of collision induced dissociation of PFAMs. A select group of PFAM standards, 12 to 22 length carbon chains, were directly infused into an electrospray ionization source Quadrupole Time of Flight Mass Spectrometer. All standards were monitored in positive mode using the [M + H]+ peak. Mass Hunter Qualitative Analysis software was used to calculate empirical formulas of the product ions. All PFAMs showed losses of 14 m/z indicative of an acyl chain, while the monounsaturated group displayed neutral losses corresponding to H2O and NH3. The resulting spectra were used to propose fragmentation mechanisms. Isotopically labeled PFAMs were used to validate the proposed mechanisms. Patterns of saturated versus unsaturated standards were distinctive, allowing for simple differentiation. This determination will allow for fast, qualitative identification of PFAMs. Additionally, it will provide a method development tool for selection of unique product ions when analyzed in multiple reaction monitoring mode.
- Divito, Erin B.,Davic, Andrew P.,Johnson, Mitchell E.,Cascio, Michael
-
experimental part
p. 2388 - 2394
(2012/07/27)
-
- Mixed Monolayers for the Design of Structured Surfaces To Induce Oriented 3-D Crystallization
-
Mixed monolayers containing two different amphiphiles C19H39CONHCH2CH2CO2H(A) and C19H39CONH2(B) were designed in order to form a two-dimensional (2-D) crystalline solid solution in which the A-type molecules form domains within the sea of B-type molecules.A "continuous" 2-D arrangement of the aliphatic chains was expected, driven by the amide hydrogen bonding requirement; a tendency for the formation of the embeded A-type domains should be provided by the interactions between the -CH2CH2CO2H head group moieties.The mixed monolayers served to promote the oriented nucleation of silver propionate 3-D crystals attached at the monolayer-solution interface.Only the A-type domains induced silver propionate crystallization whereas the B-type domains were essentially inert.The mixed A + B monolayers were found to be efficient nucleators down to a 1:10 molar ratio, providing proof for the existence of A-type domains.Additional information such as the structure and ion-binding properties of the mixed monolayers was furnished by specular X-ray reflectivity and grazing incidence X-ray diffraction using synchrotron radiation.
- Weissbuch, I.,Majewski, J.,Kjaer, K.,Als-Nielsen, J.,Lahav, M.,Leiserowitz, L.
-
p. 12848 - 12857
(2007/10/02)
-
