(R)-tert-butoxycarbonylamino-fluorenylmethoxycarbonyl-glycine from (S)-benzyloxycarbonyl-serine or from papain resolution of the corresponding amide or methyl ester
The enantiospecific synthesis of (R)-Boc-(Fmoc)-aminoglycine 7 was achieved. (S)-Cbz-serine 1 was reacted with diphenylphosphoryl azide in the presence of triethylamine to yield cyclic(S) carbamate 2. The ring nitrogen of 2 was protected with a Boc group.
Sypniewski, Michal,Penke, Botond,Simon, Lajos,Rivier, Jean
p. 6595 - 6600
(2007/10/03)
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