306935-78-4

Basic information

• Product Name: 4-[(5-METHYLISOXAZOL-3-YL)AMINO]-4-OXOBUT-2-ENOIC ACID
• Synonyms: 4-[(5-METHYLISOXAZOL-3-YL)AMINO]-4-OXOBUT-2-ENOIC ACID
• CAS NO: 306935-78-4
• Molecular Formula: C8H8N2O4
• Molecular Weight: 196.16
• Mol File: 306935-78-4.mol

Chemical Properties

• Melting Point: 165 °C
• Boiling Point: 498°Cat760mmHg
• Flash Point: 255°C
• Appearance: /
• Density: 1.441g/cm³
• Vapor Pressure: 9.76E-11mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: 4-[(5-METHYLISOXAZOL-3-YL)AMINO]-4-OXOBUT-2-ENOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(5-METHYLISOXAZOL-3-YL)AMINO]-4-OXOBUT-2-ENOIC ACID(306935-78-4)
• EPA Substance Registry System: 4-[(5-METHYLISOXAZOL-3-YL)AMINO]-4-OXOBUT-2-ENOIC ACID(306935-78-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 306935-78-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H8N2O4/c1-5-4-6(10-14-5)9-7(11)2-3-8(12)13/h2-4H,1H3,(H,12,13)(H,9,10,11)/b3-2+

Upstream product

• 108-31-6 maleic anhydride 
• 1072-67-9 5-methylisoxazol-3-ylamine 

Relevant articles and documents

Synthesis and anticancer evaluation of novel isoxazole/pyrazole derivatives

The key intermediate 3-amino-5-methylisoxazole (1) was allowed to react with phthalic anhydride and/or maleic anhydride under different conditions to produce different isoxazole products. Schiff bases 9a-c obtained via the reaction of 1 with different aldehydes were condensed with thioglycolic acid to afford the corresponding thiazolidin-4-one derivatives 10a, b. Furthermore, condensation of the Schiff bases 9a, c with various secondary amines produced the corresponding 5-substituted pyrazole derivatives 11a-d, respectively. The anticancer activity of some of the newly synthesized compounds was evaluated against Panc-1 and Caco-2 cell lines using doxorubicin as a standard drug. Most of the tested derivatives exhibited high cytotoxic potency against Panc-1 carcinoma cell lines, but moderate to weak activity was obtained against Caco-2 cell lines.

Synthesis and in vitro study of novel isoxazolyl benzoimidazolyl benzamides, acrylamides and propionamides as antimicrobial agents

A series of novel 2/3 (1H-benzoimidazol-2-yl)-N-(5-methyl-3-isoxazolyl)- benzamides, acrylamides and propionamides have been synthesized and the antimicrobial activities are evaluated against two Gram-positive and two Gram-negative bacteria and two plant-pathogenic fungi. Some of the synthesized compounds have showed superior in vitro activities as compared to the standard drugs.

Synthesis of N-Aryl/heteroaryl/-substituted-methyl-&α-(p-substituted anilino)succinimides as Antituberculosis Agents

A series of N-Aryl/heteroaryl/substituted-methyl-α-(p-substituted anilino)succinimides (II) have been prepared and screened in vitro against H37Rv strain of Mycobacterium tuberculosis.Some of these compounds exhibit activity upto 0.39 μg/ml concentration.

Synthesis of N-Aryl/substituted-methyl/heteroaryl-&α-pyrrolidino/piperidino Succinimides as Antituberculosis Agents

A series of N-Aryl/substituted-methyl/heteroaryl-α-pyrrolidino- and piperidino-succinimides (II) have been prepared and screened in vitro against H37Rv strain of Mycobacterium tuberculosis.Some of these compounds exhibit activity upto 1.56 μg/ml concentration.