308298-17-1Relevant articles and documents
Synthesis of benzimidazole–based analogs as anti alzheimer’s disease compounds and their molecular docking studies
Adalat, Bushra,Ali, Zarshad,Alshamrani, Foziah J.,Anouar, El Hassane,Rahim, Fazal,Shah, Syed Adnan Ali,Taha, Muhammad,Uddin, Nizam,Zakaria, Zainul Amiruddin
, (2020)
We synthesized 10 analogs of benzimidazole-based thiosemicarbazide 1 (a–j) and 13 benzimidazole-based Schiff bases 2 (a–m), and characterized by various spectroscopic techniques and evaluated in vitro for acetylcholinesterase (AchE) and butyrylcholinester
Synthesis, in vitro urease inhibitory potential and molecular docking study of Benzimidazole analogues
Zaman, Khalid,Rahim, Fazal,Taha, Muhammad,Ullah, Hayat,Wadood, Abdul,Nawaz, Mohsan,Khan, Fahad,Wahab, Zainul,Shah, Syed Adnan Ali,Rehman, Ashfaq Ur,Kawde, Abdel-Nasser,Gollapalli, Mohammed
, (2019)
Despite of many diverse biological activities exhibited by benzimidazole scaffold, it is rarely explored for the urease inhibitory potential. For that purpose, benzimidazole analogues 1–19 were synthesized and screened for in vitro urease inhibitory poten
BENZIMIDAZOLE DERIVATIVES AS MITOCHONDRIAL FUNCTION MODULATORS
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, (2014/05/07)
Provided are a benzimidazole derivative modulating mitochondrial functions and having pharmaceutical activity as a neuro-protective agent, and a pharmaceutical composition including the compound as an active ingredient.
4-(Heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides and their analogs as a novel class of histone deacetylase inhibitors
Frechette, Sylvie,Leit, Silvana,Woo, Soon Hyung,Lapointe, Guillaume,Jeannotte, Guillaume,Moradei, Oscar,Paquin, Isabelle,Bouchain, Giliane,Raeppel, Stephane,Gaudette, Frederic,Zhou, Nancy,Vaisburg, Arkadii,Fournel, Marielle,Yan, Pu Theresa,Trachy-Bourget, Marie-Claude,Kalita, Ann,Robert, Marie-France,Lu, Aihua,Rahil, Jubrail,Robert MacLeod,Besterman, Jeffrey M.,Li, Zuomei,Delorme, Daniel
, p. 1502 - 1506 (2008/09/19)
The synthesis and biological evaluation of a variety of 4-(heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides and their analogs is described. Some of these compounds were shown to inhibit HDAC1 with IC50 values below the micromolar range, indu
HISTONE DEACETYLASE INHIBITORS
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Page/Page column 53, (2008/06/13)
Compounds, pharmaceutical compositions, kits and methods are provided for use with histone deacetylases (HDACs) that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
Inhibitors of histone deacetylase
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, (2008/06/13)
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
Inhibitors of histone deacetylase
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, (2008/06/13)
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
Inhibitors of histone deacetylase
-
, (2008/06/13)
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
2-substituted benzimidazole derivatives
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, (2008/06/13)
Disclosed herein are compounds of the formula: STR1 where R1 is substituted phenyl in which the substituents are one or two halogens, alkyl groups, carboxyl groups or alkoxycarbonyl groups; R2 is H or alkyl; R3 and R4
