309253-36-9

Basic information

• Product Name: 2-iodo-5-MethylbenzaMide
• Synonyms: 2-iodo-5-MethylbenzaMide
• CAS NO: 309253-36-9
• Molecular Formula: C₈H₈INO
• Molecular Weight: 261.05969
• Mol File: 309253-36-9.mol

Chemical Properties

• Boiling Point: 291.2±33.0 °C(Predicted)
• Appearance: /
• Density: 1.782±0.06 g/cm3(Predicted)
• PKA: 15.57±0.50(Predicted)
• CAS DataBase Reference: 2-iodo-5-MethylbenzaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-iodo-5-MethylbenzaMide(309253-36-9)
• EPA Substance Registry System: 2-iodo-5-MethylbenzaMide(309253-36-9)

Safety Data

• Hazardous Substances Data: 309253-36-9(Hazardous Substances Data)

Upstream product

• 52548-14-8 2-iodoyl-5-methylbenzoic acid 
• 52107-96-7 2-iodo-5-methylbenzoyl chloride 

Downstream Products

• 1133467-90-9 [N-(trifluoromethanesulfonyl)imino](2-carbamoyl-4-methylphenyl)-λ3-iodane 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 21419-51-2 6-methyl-2-phenylquinazolin-4(3H)-one 
• 40314-06-5 5-methyl-1H-isoindole-1,3-(2H)-dione 

Relevant articles and documents

PPh3/I2/HCOOH: An efficient CO source for the synthesis of phthalimides

A straightforward and general method has been developed for the synthesis of phthalimide derivatives from 2-iodobenzamides and PPh3/I2/HCOOH in the presence of a catalytic amount of Pd(OAc)2. The reaction results demonstrate that PPh3/I2/HCOOH is a facile, efficient and safe CO source. The whole process is carried out in toluene at 80 °C and furnishes the desired products in good to excellent yields.

Direct Difluorination-Hydroxylation, Trifluorination, and C(sp2)-H Fluorination of Enamides

A direct double functionalization involving both difluorination and hydroxylation of enamides is reported. With the appropriate combination of an electrophilic fluorinating reagent and H2O, the most convenient and ecofriendly hydroxylating agent, the preparation of 3-(difluoroalkyl)-3-hydroxyisoindolin-1-ones was achieved under basic or Br?nsted acidic conditions. Suitable conditions for trifluorination as well as C(sp2)-H fluorination were also identified. Subsequent asymmetric functionalization of the obtained gem-difluorinated products has also been demonstrated.

Magnetically recyclable copper modified GO/Fe3O4 catalyst for efficient synthesis of quinazolinones

A series of bioactive quinazolinones were effectively synthesized by the condensation of halide benzamide with amino acid using magnetically recyclable GO/Fe3O4-CuI as catalyst. Magnetic GO/Fe3O4-CuI was prepared via a simple chemical method and characterized by FTIR, powder XRD, and SEM. This heterogeneous copper catalyst can be easily separated from reaction mixtures by an external permanent magnet and reused without any obvious loss in activity which shows its applicability as a reusable and promising catalyst for quinazolinones synthesis.