309263-43-2Relevant articles and documents
Highly enantioselective spinol-derived phosphoric acid catalyzed transfer hydrogenation of diverse C=N-containing heterocycles
Zhang, Yiliang,Zhao, Rong,Bao, Robert Li-Yuan,Shi, Lei
supporting information, p. 3344 - 3351 (2015/05/20)
A highly efficient and enantioselective hydrogenation of diversely substituted C=N-containing heterocyclic compounds such as 3-aryl-1,4-benzoxazines and 2-arylquinolines was experimentally explored by using 1,1′-spirobiindane-7,7′-diol-derived chiral phosphoric acids as the catalyst. This method provides straightforward access to the corresponding tetrahydroquinolines and dihydro-2H-1,4-benzothiazines in high yields (85-99%) with excellent enantioselectivities (91-99%). The attractive features of this procedure, which include mild reaction conditions, operational simplicity, relatively low catalyst loading (1 mol-%), and high levels of enantioselectivities, make it a useful approach for the practical synthesis of optically active nitrogen-containing aromatic heterocycles.
A novel reduction of o-nitrophenoxy compounds promoted by low-valent titanium: An access to 2H-1,4-benzoxazine derivatives
Ma,Zhang
, p. 388 - 389 (2007/10/03)
The intramolecular reductive cyclizations of o-nitrophenoxyacetophenones, o-nitrophenoxyacetate and o-nitrophenoxyacetonitrile induced by the Sm/TiCl4 system were studied; 2H-1,4-benzoxazines are obtained in high yields under room temperature conditions.
