Synthesis and DNA cleavage of 2′-O-amino-linked metalloporphyrin-oligonucleotide conjugates
A new general method for an easy 2′-O-modification of nucleosides is reported. We describe the preparation of modified 19-mer oligonucleotides carrying an aminoalkyl linker at the 2′-position of cytidine residues and the covalent attachment of an artifici