310443-54-0

Basic information

• Product Name: ethyl 4-hydroxy-5-methoxypyrrolo[1,2-f][1,2,4]triazine-6-carboxylate
• Synonyms: ethyl 4-hydroxy-5-methoxypyrrolo[1,2-f][1,2,4]triazine-6-carboxylate
• CAS NO: 310443-54-0
• Molecular Formula: C10H11N3O4
• Molecular Weight: 237.21204
• Mol File: 310443-54-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 4-hydroxy-5-methoxypyrrolo[1,2-f][1,2,4]triazine-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-hydroxy-5-methoxypyrrolo[1,2-f][1,2,4]triazine-6-carboxylate(310443-54-0)
• EPA Substance Registry System: ethyl 4-hydroxy-5-methoxypyrrolo[1,2-f][1,2,4]triazine-6-carboxylate(310443-54-0)

Safety Data

• Hazardous Substances Data: 310443-54-0(Hazardous Substances Data)

Upstream product

• 77287-34-4 formamide 
• 310444-77-0 diethyl 1-amino-3-methoxypyrrole-2,4-dicarboxylate 

Downstream Products

• 310444-78-1 4-Chloro-5-methoxypyrrolo[2,1-f][1,2,4]triazine-6-carboxylic Acid Ethyl Ester 

Relevant articles and documents

Pyrrolotriazine inhibitors of kinases

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors

Methods of treating one or more conditions associated with p38 kinase activity are disclosed comprising administering to a patient in need thereof at least one compound having the formula (I): 1or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R3 is hydrogen, methyl, perfluoromethyl, methoxy, halogen, cyano, or NH2, preferably methyl, and X, R1 through R6, and Z are as described in the specification. Advantageously the groups —ZR4R5 taken together comprise an —NH-substituted aryl.