- INDAZOLE DERIVATIVES USEFUL AS MELANIN CONCENTRATING RECEPTOR LIGANDS
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The present invention relates to novel compounds, in particular, novel indazole that may be used as melanin concentrating hormone receptor ligands, methods of preparing such compounds, compositions containing such compounds, and methods of using such compounds to treat MCH related disorders.
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Page/Page column 51
(2008/12/05)
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- BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS
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The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.
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Page/Page column 56
(2010/11/28)
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- Azoles. Part 32: Nitroindazole derivatives and their electron affinity
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A modified procedure for the synthesis of the dinitroindazoles 5-8 is described. Treatment of the chloronitro- and dinitroindazoles 1-8 with epichlorohydrin afforded the chlorohydroxypropyl- and epoxypropylindazole derivatives 2a-8a, 1b-5b, 7b and 7c. The structure of the compounds is confirmed by the aid of their IR, 1H and 13C NMR spectra. The electron affinity of the nitroindazole derivatives 1-16 is discussed on the basis of their halfwave potentials and in the combination with their eventual radiosensitizing properties.
- Usarewicz,Wrzeciono,Lukaszewski,Gatniejewska,Peisert
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