312697-17-9Relevant articles and documents
COMPOUNDS FOR TREATING VIRAL INFECTIONS
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Page/Page column 81; 82, (2015/11/09)
The present invention relates to small molecule compounds and their use in the treatment of diseases, in particular viral diseases, in particular hepatitis C virus (HCV).
New Convenient Strategy for Annulation of Pyrimidines to Thiophenes or Furans via the One-pot Multistep Cascade Reaction of 1 H -Tetrazoles with Aliphatic Amines
Pokhodylo, Nazariy T.,Shyyka, Olga Ya.,Matiychuk, Vasyl S.,Obushak, Mykola D.
, p. 399 - 403 (2016/01/15)
A versatile, convenient, efficient and high-yield synthetic method for 2-R3,R4-amino-5-R1-6-R2-thieno[2,3-d]pyrimidin-4(3H)-ones, 2-R3,R4-amino-5-R1-6-R2-thieno[3,2-d]pyrimidin-4(3H)-ones, and benzofuro[3,2-d]pyrimidin-4(3H)-ones preparation has been developed. The reaction proceeded without using solvents and included several steps. A variety of thieno[2,3-d]pyrimidine and thieno[3,2-d]pyrimidine derivatives with substituents of different nature were obtained in high yields from substituted alkyl 2-(1H-tetrazol-1-yl)thiophene-3-carboxylates, 3-(1H-tetrazol-1-yl)thiophene-2-carboxylates, and 3-(1H-tetrazol-1-yl)benzofuran-2-carboxylate after their treatment with aliphatic amines.
Facile and efficient one-pot procedure for thieno[2,3-e][1,2,3]triazolo[1, 5-a]pyrimidines preparation
Pokhodylo, Nazariy T.,Shyyka, Olga Y.,Obushak, Mykola D.
, p. 1002 - 1006 (2014/03/21)
Base-catalyzed cycloaddition reactions of heterocyclic azides with activated nitriles were studied. Convenient, efficient, and high-yield synthetic method for thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines preparation from available starting reagents without complicated protocols was elaborated. Such an approach allows creation of broad combinatorial libraries for drug discovery. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
KF/Al2O3/PEG-400: An efficient catalytic system for the fiesselmann-type synthesis of thiophene derivatives
Bezboruah, Pranjal,Gogoi, Pranjal,Gogoi, Junali,Boruah, Romesh C.
, p. 1341 - 1348 (2013/06/27)
A simple and mild protocol has been developed for the synthesis of novel steroidal and nonsteroidal thiophene derivatives from β-halo-α, β-unsaturated aldehydes using KF/Al2O3/PEG-400 as an efficient catalytic system. The β-halo-α,β-
Novel Antiviral Compounds
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Paragraph 0463, (2013/09/26)
The present invention relates to compounds of formula (A), as further defined herein, having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. The invention further relates to the use of such compounds, optionally combined with one or more other drugs having antiviral activity, for the treatment of animals suffering from viral infections, in particular HIV infection.
NOVEL ANTIVIRAL COMPOUNDS
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Page/Page column 87-88, (2012/06/01)
The present invention relates to compounds of formula (A), as further defined herein, having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting 5 properties. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. The invention further relates to the use of such compounds, optionally combined with one or more other drugs having antiviral activity, for the treatment of animals suffering from viral infections, in particular HIV infection.
A new and facile synthesis of methyl 3-amino-4,5,6,7-tetrahydrobenzo[b] thiophene-2-carboxylate
Tenora, Luká?,Buchlovi?, Marian,Man, Stanislav,Potá?ek, Milan
scheme or table, p. 401 - 403 (2011/02/28)
A four-step synthesis of methyl 3-amino-4,5,6,7-tetrahydrobenzo[b] thiophene-2-carboxylate from commercially available starting materials is presented.
Thieno-and furo-pyrimidine modulators of the histamine H4 receptor
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Page/Page column 13, (2009/04/24)
Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.