- Base-catalyzed synthesis of substituted indazoles under mild, transition-metal-free conditions
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Back to basics: A transition-metal-free method developed for the synthesis of indazoles involves an inexpensive catalytic system composed of a diamine and K2CO3. Various (Z)-2-bromoacetophenone tosylhydrazones were converted into indazoles at room temperature in excellent yields (see example; Ts=p-toluenesulfonyl). The yield was improved by photoisomerization with UV light when E/Z isomeric mixtures of the starting material were used. Copyright
- Thome, Isabelle,Besson, Claire,Kleine, Tillmann,Bolm, Carsten
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- Processes for preparing 6-alkyl-5-arylsulfonyl-dihydrophenanthridines
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Synthetic methods are provided for production of compounds of the formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are as defined in the specification.
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Page/Page column 9-10
(2010/02/15)
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