314042-78-9

Basic information

• Product Name: N-(3-(9H-carbazol-9-yl)-2-hydroxypropyl)-N-phenylmethanesulfonamide
• Synonyms: N-(3-(9H-carbazol-9-yl)-2-hydroxypropyl)-N-phenylmethanesulfonamide
• CAS NO: 314042-78-9
• Molecular Formula: C22H22N2O3S
• Molecular Weight: 394.48668
• Mol File: 314042-78-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-(9H-carbazol-9-yl)-2-hydroxypropyl)-N-phenylmethanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-(9H-carbazol-9-yl)-2-hydroxypropyl)-N-phenylmethanesulfonamide(314042-78-9)
• EPA Substance Registry System: N-(3-(9H-carbazol-9-yl)-2-hydroxypropyl)-N-phenylmethanesulfonamide(314042-78-9)

Safety Data

• Hazardous Substances Data: 314042-78-9(Hazardous Substances Data)

Upstream product

• 52131-82-5 9-(oxiran-2-ylmethyl)-9H-carbazole 
• 1197-22-4 N-phenylmethanesulfonamide 
• 62-53-3 aniline 
• 86-74-8 9H-carbazole 

Relevant articles and documents

Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents

A series of novel carbazole-containing sulfonamides and sulfamides were synthesized. A structure-activity relationship study of these compounds led to the identification of potent cryptochrome modulators. Based on the results of efficacy studies in diet-induced obese (DIO) mice, and the desired pharmacokinetic parameters, compound 41 was selected for further profiling.

Carbazole-Containing Sulfonamides as Cryptochrome Modulators

The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, F, G, H, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome, and glaucoma.