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314291-83-3

4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid sodium salt hydrate, also known as Phenylhydrazono pyrazolone sulfonate 1 (PHPS1) sodium salt hydrate, is a chemical compound with a complex structure. It is a protein-tyrosine phosphatase (shp2) inhibitor and has been studied for its effects on cell proliferation and potential pro-atherosclerotic or atheroprotective effects.

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  • 4-{2-3-(4-nitrophenyl)-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-ylidenehydrazin-1-yl}benzene-1-sulfonic acid;314291-83-3

    Cas No: 314291-83-3

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  • Amadis Chemical Co., Ltd.
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  • 4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid sodium salt hydrate

    Cas No: 314291-83-3

  • USD $ 10.0-10.0 / Milligram

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  • weifang yangxu group co.,ltd
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  • 314291-83-3 Structure

  • Basic information

    1. Product Name: 4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid sodium salt hydrate
    2. Synonyms: 4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid sodium salt hydrate;PHPS1 sodium salt hydrate;PTP Inhibitor V, PHPS1;PHPS1 sodium salt;PHPS1
    3. CAS NO:314291-83-3
    4. Molecular Formula: C23H19N5O6S
    5. Molecular Weight: 493.49186
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 314291-83-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: red/
    5. Density: 1.54±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: DMSO: soluble10mg/mL, clear (warmed)
    9. PKA: -2.90±0.40(Predicted)
    10. CAS DataBase Reference: 4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid sodium salt hydrate(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid sodium salt hydrate(314291-83-3)
    12. EPA Substance Registry System: 4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid sodium salt hydrate(314291-83-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 2
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 314291-83-3(Hazardous Substances Data)

314291-83-3 Usage

Uses

Used in Pharmaceutical Research:
PHPS1 sodium salt hydrate is used as a protein-tyrosine phosphatase (shp2) inhibitor for studying its effects on bisphenol A (BPA) and nonyl phenol (NP)-induced cell proliferation of MCF7 cells. This research helps in understanding the role of shp2 in cell proliferation and the potential therapeutic applications of PHPS1 sodium salt hydrate in treating diseases related to abnormal cell growth.
Used in Cardiovascular Research:
PHPS1 sodium salt hydrate is used as a shp2 inhibitor to study its pro-atherosclerotic or atheroprotective effects in vivo and in vitro. This research is crucial for understanding the role of shp2 in atherosclerosis and the potential of PHPS1 sodium salt hydrate as a therapeutic agent for cardiovascular diseases.

Biochem/physiol Actions

Phenylhydrazono pyrazolone sulfonate 1 (PHPS1) represses E2-induced gene transcription and rapid DNA synthesis. It also blocks mitogen-activated protein kinase (ERK1/2) activation and reduces the cigarette smoke induced-inflammatory response in mouse lungs.

Check Digit Verification of cas no

The CAS Registry Mumber 314291-83-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,4,2,9 and 1 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 314291-83:
(8*3)+(7*1)+(6*4)+(5*2)+(4*9)+(3*1)+(2*8)+(1*3)=123
123 % 10 = 3
So 314291-83-3 is a valid CAS Registry Number.

314291-83-3 Well-known Company Product Price

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  • Sigma

  • (P0039)  PHPS1 sodium salt hydrate  ≥98% (HPLC)

  • 314291-83-3

  • P0039-5MG

  • 1,749.15CNY

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  • Sigma

  • (P0039)  PHPS1 sodium salt hydrate  ≥98% (HPLC)

  • 314291-83-3

  • P0039-25MG

  • 6,885.45CNY

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314291-83-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name PHPS1 sodium salt hydrate

1.2 Other means of identification

Product number -
Other names [4-[2-[3-[4-(nitromethyl)phenyl]-5-oxo-1-phenylpyrazol-4-ylidene]hydrazinyl]phenyl]methanesulfonic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:314291-83-3 SDS

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