- A Convenient Preparation of 4,8-Dimethoxy-3-substituted-2(1H)-quinolones by an Electrophilic Reaction through Base-induced Deprotonation and its Synthetic Application for the Synthesis of New Alkaloids, 3,4,8-Trimethoxy-2(1H)-quinolone and 3-Formyl-4,7,8-trimethoxy-2(1H)-quinolone(Glycocitridine)
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Some 4,8-dimethoxy-3-substituted-2(1H)-quinolones were prepared by electrophilic reaction of 4,8-dimethoxy-2(1H)-quinolone with electrophiles in the presence of n-butyllithium-N,N,N',N',-tetramethylethylenediamine in fairly good yields. This present method was successfully applied for the synthesis of two new alkaloids bearing the 4,8-dimethoxy-2(1H)-quinolone skeleton.
- Tagawa, Yoshinobu,Kawaoka, Takamitsu,Goto, Yoshinobu
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p. 1677 - 1683
(2007/10/03)
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- QUINOLINONE ALKALOIDS FROM AN AGATHOSMA SPECIES
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The aerial parts of a new species from the genus Agathosma yielded skimmianine and two new alkaloids which were identified by means of spectral data and synthesis as 4,6-dimethoxy-1-methyl-2(1H)-quinolinone and 2,6-dihydro-9-methoxy-2,2,6-trimethyl-5H-pyr
- Campbell, William E.,Davidowitz, Bette,Jackson, Graham E.
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p. 1303 - 1306
(2007/10/02)
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