- Meta -C-H arylation of fluoroarenes via traceless directing group relay strategy
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While several methods for the ortho selective arylation of fluoroarenes, meta-functionalisation has never been achieved. We report a new methodology, based on the traceless directing group relay concept, leading to the first meta-selective (hetero)arylation of fluoroarenes. In this strategy, CO2 is introduced as a transient directing group, to control a Pd-catalysed arylation meta to the fluoro functionality, prior to its release in a sequential, one-pot fashion. This method has shown compatibility with a number of functional groups and substitution patterns in both the fluoroarene core and aryl iodide coupling partners, and proceeds with complete meta-selectivity and mono vs. bis-arylation selectivity.
- Font, Marc,Spencer, Andrew R. A.,Larrosa, Igor
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p. 7133 - 7137
(2018/09/25)
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- Discovery of selective metal-binding peptoids using 19F encoded combinatorial libraries
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A method for encoding solid-phase split/mix combinatorial libraries using the chemical shift of synthetic fluoroarenes ('F-codes') has been developed. They have wide chemical shift dispersion and are detectable at the sub-μmol level. 19F NMR is
- Pirrung, Michael C.,Park, Kaapjoo
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p. 2115 - 2118
(2007/10/03)
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