- Pd/Cu-Catalyzed C-H/C-H Cross Coupling of (Hetero)Arenes with Azoles through Arylsulfonium Intermediates
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A highly efficient method for the selective formal C-H/C-H cross-coupling of azoles and (hetero)arenes was established through arylsulfonium intermediates under transition-metal catalysis, which produced a variety of 2-(hetero)aryl azoles in good to excellent yields. Advantages of the reaction included mildness, a good functional group tolerance, a wide range of substrates, a high regio- and chemoselectivity, one-pot procedures, and the late-stage functionalization of complex molecules without the use of oxidants, offering a promising strategy for the transition-metal-catalyzed C-H arylation of azoles.
- Lin, Zeng-Hui,Tian, Ze-Yu,Zhang, Cheng-Pan
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- NITRIC OXIDE DONORS FOR TREATING INFLAMMATORY BOWEL DISEASES
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Use of a novel class of NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, in the treatment of inflammatory bowel diseases is disclosed.
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Page/Page column 59
(2008/06/13)
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- NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMA AGONISTS
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The present invention relates to compounds of formula (I) wherein Rl to R10, X, Y and n are as defined in the description and claims, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment of diseases such as diabetes.
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