Welcome to LookChem.com Sign In|Join Free

CAS

  • or
1,2,3,4-Tetrahydro-2,6-naphthyridine is an organic compound with a unique chemical structure, characterized by a fused six-membered and five-membered nitrogen-containing ring system. It serves as an important intermediate in the synthesis of various pharmaceutical compounds due to its versatile reactivity and structural properties.

31786-18-2 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 31786-18-2 Structure
  • Basic information

    1. Product Name: 1,2,3,4-tetrahydro-2,6-naphthyridine
    2. Synonyms: 1,2,3,4-tetrahydro-2,6-naphthyridine;2,6-Naphthyridine, 1,2,3,4-tetrahydro-;1,2,3,4-Tetrahydro-2,6-naphthyridin
    3. CAS NO:31786-18-2
    4. Molecular Formula: C8H10N2
    5. Molecular Weight: 134.18
    6. EINECS: N/A
    7. Product Categories: Heterocycle-other series;Heterocycle-Pyridine series
    8. Mol File: 31786-18-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 244.473 °C at 760 mmHg
    3. Flash Point: 101.654 °C
    4. Appearance: /
    5. Density: 1.069 g/cm3
    6. Vapor Pressure: 0.03mmHg at 25°C
    7. Refractive Index: 1.548
    8. Storage Temp.: 2-8°C(protect from light)
    9. Solubility: N/A
    10. PKA: 7.74±0.20(Predicted)
    11. CAS DataBase Reference: 1,2,3,4-tetrahydro-2,6-naphthyridine(CAS DataBase Reference)
    12. NIST Chemistry Reference: 1,2,3,4-tetrahydro-2,6-naphthyridine(31786-18-2)
    13. EPA Substance Registry System: 1,2,3,4-tetrahydro-2,6-naphthyridine(31786-18-2)
  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 31786-18-2(Hazardous Substances Data)

31786-18-2 Usage

Uses

Used in Pharmaceutical Industry:
1,2,3,4-Tetrahydro-2,6-naphthyridine is used as a key intermediate in the synthetic preparation of quinolizidinone carboxylic acid selective M1 allosteric modulators. These modulators play a crucial role in the development of novel therapeutic agents targeting the M1 muscarinic receptor, which is implicated in various neurological and cognitive disorders, such as Alzheimer's disease and schizophrenia. 1,2,3,4-tetrahydro-2,6-naphthyridine's unique structure allows for the fine-tuning of the modulators' properties, enabling the design of more effective and selective drugs for these conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 31786-18-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,7,8 and 6 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 31786-18:
(7*3)+(6*1)+(5*7)+(4*8)+(3*6)+(2*1)+(1*8)=122
122 % 10 = 2
So 31786-18-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2/c1-3-9-6-8-2-4-10-5-7(1)8/h1,3,6,10H,2,4-5H2

31786-18-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,2,3,4-Tetrahydro-2,6-naphthyridine

1.2 Other means of identification

Product number -
Other names Tetrahydro-2,6-naphthyridin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:31786-18-2 SDS

31786-18-2Relevant articles and documents

High-Throughput Screening and Hit Validation of Extracellular-Related Kinase 5 (ERK5) Inhibitors

Myers, Stephanie M.,Bawn, Ruth H.,Bisset, Louise C.,Blackburn, Timothy J.,Cottyn, Betty,Molyneux, Lauren,Wong, Ai-Ching,Cano, Celine,Clegg, William,Harrington, Ross. W.,Leung, Hing,Rigoreau, Laurent,Vidot, Sandrine,Golding, Bernard T.,Griffin, Roger J.,Hammonds, Tim,Newell, David R.,Hardcastle, Ian R.

, p. 444 - 455 (2016/08/16)

The extracellular-related kinase 5 (ERK5) is a promising target for cancer therapy. A high-throughput screen was developed for ERK5, based on the IMAP FP progressive binding system, and used to identify hits from a library of 57-617 compounds. Four distinct chemical series were evident within the screening hits. Resynthesis and reassay of the hits demonstrated that one series did not return active compounds, whereas three series returned active hits. Structure-activity studies demonstrated that the 4-benzoylpyrrole-2-carboxamide pharmacophore had excellent potential for further development. The minimum kinase binding pharmacophore was identified, and key examples demonstrated good selectivity for ERK5 over p38α kinase.

PRMT5 INHIBITORS AND USES THEREOF

-

, (2016/04/20)

Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof:wherein Y1 is of formula (?) or formula (y):Ring Y is a 5- to 6-membered heteroaryl ring; and V4, V5, Rx, x, y, and n are as defined herein. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

SUBSTITUTED SULFONAMIDE COMPOUNDS

-

Page/Page column 57, (2008/12/06)

Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.

Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition

-

, (2008/06/13)

The present invention provides a compound of formula (I) in which R1 is generally hydrogen or CF3, R2 is generally hydrogen, W is a cyclic amine, a heterocycle or a group L-Y-X where L-Y is a linking portion and X is generally an aromatic or non-aromatic heterocycle, alkyl or alkylcarbonyl and Z is generally a heterocycle such as 5-methylisoxazol-3-yl, and pharmaceutically acceptable salts thereof for enhancing cognition in conditions such as Alzheimer's Disease, pharmaceutical compositions comprising them, their use for manufacturing medicaments and methods of treatment using them.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 31786-18-2