31786-18-2

Basic information

• Product Name: 1,2,3,4-tetrahydro-2,6-naphthyridine
• Synonyms: 1,2,3,4-tetrahydro-2,6-naphthyridine;2,6-Naphthyridine, 1,2,3,4-tetrahydro-;1,2,3,4-Tetrahydro-2,6-naphthyridin
• CAS NO: 31786-18-2
• Molecular Formula: C₈H₁₀N₂
• Molecular Weight: 134.18
• Product Categories: Heterocycle-other series;Heterocycle-Pyridine series
• Mol File: 31786-18-2.mol

Chemical Properties

• Boiling Point: 244.473 °C at 760 mmHg
• Flash Point: 101.654 °C
• Appearance: /
• Density: 1.069 g/cm³
• Vapor Pressure: 0.03mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: 2-8°C(protect from light)
• PKA: 7.74±0.20(Predicted)
• CAS DataBase Reference: 1,2,3,4-tetrahydro-2,6-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-tetrahydro-2,6-naphthyridine(31786-18-2)
• EPA Substance Registry System: 1,2,3,4-tetrahydro-2,6-naphthyridine(31786-18-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 31786-18-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,2,3,4-Tetrahydro-2,6-naphthyridine is used as a key intermediate in the synthetic preparation of quinolizidinone carboxylic acid selective M1 allosteric modulators. These modulators play a crucial role in the development of novel therapeutic agents targeting the M1 muscarinic receptor, which is implicated in various neurological and cognitive disorders, such as Alzheimer's disease and schizophrenia. 1,2,3,4-tetrahydro-2,6-naphthyridine's unique structure allows for the fine-tuning of the modulators' properties, enabling the design of more effective and selective drugs for these conditions.

InChI:InChI=1/C8H10N2/c1-3-9-6-8-2-4-10-5-7(1)8/h1,3,6,10H,2,4-5H2

Upstream product

• 1165952-92-0 cyclohexa-1,4-diene 
• 222167-62-6 3-(trimethylsilylethynyl)pyridine-4-carboxaldehyde 
• 70201-43-3 3-bromo-pyridine-4-carbaldehyde 
• 626-55-1 3-Bromopyridine 
• 253-50-9 2,6-naphthyridine 

Downstream Products

• 1018827-38-7 1-(3,4-dihydro-2,6-naphthyridin-2(1H)-yl)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone 
• 1362159-41-8 C₂₂H₂₁N₃O₃S 

Relevant articles and documents

High-Throughput Screening and Hit Validation of Extracellular-Related Kinase 5 (ERK5) Inhibitors

The extracellular-related kinase 5 (ERK5) is a promising target for cancer therapy. A high-throughput screen was developed for ERK5, based on the IMAP FP progressive binding system, and used to identify hits from a library of 57-617 compounds. Four distinct chemical series were evident within the screening hits. Resynthesis and reassay of the hits demonstrated that one series did not return active compounds, whereas three series returned active hits. Structure-activity studies demonstrated that the 4-benzoylpyrrole-2-carboxamide pharmacophore had excellent potential for further development. The minimum kinase binding pharmacophore was identified, and key examples demonstrated good selectivity for ERK5 over p38α kinase.

PRMT5 INHIBITORS AND USES THEREOF

Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof:wherein Y1 is of formula (?) or formula (y):Ring Y is a 5- to 6-membered heteroaryl ring; and V4, V5, Rx, x, y, and n are as defined herein. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

SUBSTITUTED SULFONAMIDE COMPOUNDS

Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.

Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition

The present invention provides a compound of formula (I) in which R1 is generally hydrogen or CF3, R2 is generally hydrogen, W is a cyclic amine, a heterocycle or a group L-Y-X where L-Y is a linking portion and X is generally an aromatic or non-aromatic heterocycle, alkyl or alkylcarbonyl and Z is generally a heterocycle such as 5-methylisoxazol-3-yl, and pharmaceutically acceptable salts thereof for enhancing cognition in conditions such as Alzheimer's Disease, pharmaceutical compositions comprising them, their use for manufacturing medicaments and methods of treatment using them.