31872-64-7

Basic information

• Product Name: 3-Chloro-4-hydroxy-5-nitropyridine
• Synonyms: 3-Chloro-4-hydroxy-5-nitropyridine;3-Chloro-5-nitro-4-pyridinol;5-Chloro-3-nitro-4-pyridinol
• CAS NO: 31872-64-7
• Molecular Formula: C₅H₃ClN₂O₃
• Molecular Weight: 174.54
• Mol File: 31872-64-7.mol

Chemical Properties

• Melting Point: 263℃
• Boiling Point: 339.3±37.0 °C(Predicted)
• Appearance: /
• Density: 1.664±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -1.56±0.38(Predicted)
• CAS DataBase Reference: 3-Chloro-4-hydroxy-5-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-4-hydroxy-5-nitropyridine(31872-64-7)
• EPA Substance Registry System: 3-Chloro-4-hydroxy-5-nitropyridine(31872-64-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 31872-64-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-4-hydroxy-5-nitropyridine is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Chloro-4-hydroxy-5-nitropyridine serves as an intermediate for the production of agrochemicals. Its potential anti-inflammatory and antibacterial properties make it a candidate for the development of new pesticides or other agricultural chemicals.
Used in Organic Synthesis:
3-Chloro-4-hydroxy-5-nitropyridine is utilized as a valuable building block in organic synthesis. Its electrophilic substitution reactions facilitate the creation of a wide range of organic compounds for various applications.
Used in Research and Development:
3-Chloro-4-hydroxy-5-nitropyridine is employed in research and development efforts aimed at exploring its anti-inflammatory and antibacterial properties. Further studies could lead to the discovery of new treatments in the medical field and advancements in agricultural practices.

InChI:InChI=1S/C5H3ClN2O3/c6-3-1-7-2-4(5(3)9)8(10)11/h1-2H,(H,7,9)

Upstream product

• 5435-54-1 4-hydroxy-3-nitropyridine 

Downstream Products

• 1186084-29-6 4-chloro-N-({1-[(3S)-3-methylpiperazin-1-yl]cyclohexyl}methyl)-1-pyrimidin-2-yl-1H-pyrrolo[2,3-c]pyridine-3-carboxamide 
• 56809-84-8 3,4-dichloro-5-nitropyridine 

Relevant articles and documents

4 - SUBSTITUTED 1, 3 - DIHYDRO - 2H - BENZIMIDAZOL - 2 - ONE DERIVATIVES SUBSTITUTED WITH BENZIMIDAZOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS

The present invention is concerned with novel 4-substituted 1,3-dihydro-2H- benzimidazol-2-one derivatives substituted with benzimidazoles having formula (I), tautomers and stereoisomeric forms thereof, and the pharmaceutically acceptable addition salts, and the solvates thereof, wherein R4, R5, Z and Het have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.

1,3 -DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES SUBSTITUTED WITH HETEROCYCLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS

The present invention is concerned with novel 4-substituted 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles having formula (I) tautomers and stereoisomeric forms thereof, and the pharmaceutically acceptable addition salts, and the solvates thereof, wherein R4, R5, Z and Het have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.

HETEROARYL AMIDE ANALOGUES

Compounds, pharmaceutical compositions, and methods of use are disclosed for heteroaryl amide analogues of formula Ia and/or Ib. In certain embodiments, the heteroaryl amide analogues are agonists and/or ligands of dopamine receptors and may be useful, inter alia, for the treatment of a condition responsive to P2X7 receptor modulation, for example, pain, inflammation, a neurological or neurodegenerative disorder, a cardiovascular disorder, an ocular disorder or an immune system disorder.

7′-Substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors

We report on the discovery of benzo- and pyridinothiazolothiopurines as potent heat shock protein 90 inhibitors. The benzothiazole moiety is exceptionally sensitive to substitutions on the aromatic ring with a 7′-substituent essential for activity. Some of these compounds exhibit low nanomolar inhibition activity in a Her-2 degradation assay (28-150 nM), good aqueous solubility, and oral bioavailability profiles in mice. In vivo efficacy experiments demonstrate that compounds of this class inhibit tumor growth in an N87 human colon cancer xenograft model via oral administration as shown with compound 37 (8-(7-chloro-benzothiazol-2-ylsulfanyl)-9-(2-cyclopropylamino-ethyl) -9H-purin-6-ylamine).