318967-75-8

Basic information

• Product Name: [5-(4-Nitrobenzyl)thiazol-2-yl]amine
• Synonyms: [5-(4-Nitrobenzyl)thiazol-2-yl]amine;5-[(4-nitrophenyl)Methyl]-1,3-thiazol-2-aMine;5-(4-nitrobenzyl)thiazol-2-amine
• CAS NO: 318967-75-8
• Molecular Formula: C10H9N3O2S
• Molecular Weight: 235
• Mol File: 318967-75-8.mol

Chemical Properties

• Boiling Point: 451.1±25.0 °C(Predicted)
• Appearance: /
• Density: 1.420±0.06 g/cm3(Predicted)
• PKA: 4.83±0.10(Predicted)
• CAS DataBase Reference: [5-(4-Nitrobenzyl)thiazol-2-yl]amine(CAS DataBase Reference)
• NIST Chemistry Reference: [5-(4-Nitrobenzyl)thiazol-2-yl]amine(318967-75-8)
• EPA Substance Registry System: [5-(4-Nitrobenzyl)thiazol-2-yl]amine(318967-75-8)

Safety Data

• Hazardous Substances Data: 318967-75-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[5-(4-Nitrobenzyl)thiazol-2-yl]amine is used as a building block for the synthesis of bioactive compounds, contributing to the development of new drugs with potential medicinal properties. Its unique structure allows for the creation of a variety of pharmaceutical agents that can target different diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical industry, [5-(4-Nitrobenzyl)thiazol-2-yl]amine is used as a building block for the synthesis of bioactive compounds with potential applications in pest control, crop protection, and other agricultural areas. Its versatility in chemical synthesis makes it a valuable component in the development of new agrochemical products.

Upstream product

• 100-01-6 4-nitro-aniline 
• 98590-89-7 2-chloro-3-(4-nitro-phenyl)-propionaldehyde 
• 17356-08-0 thiourea 

Downstream Products

• 1242283-98-2 C₁₈H₁₅N₃O₃S 
• 1242283-99-3 C₁₉H₁₇N₃O₄S 

Relevant articles and documents

Synthesis and BK channel-opening activity of 2-amino-1,3-thiazole derivatives

A series of 2-amino-5-arylmethyl- or 5-heteroarylmethyl-1,3-thiazole derivatives were synthesized and evaluated for BK channel-opening activities in cell-based fluorescence assay and electrophysiological recording. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at benzene ring.

Design and synthesis of thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: From docking false positives to ATP-noncompetitive inhibitors

(Figure Presented) Overcoming resistance: In an effort to optimize our previously identified dual Src/Abl hits, a new series of 1,3,4-thiadiazoles and 1,3-thiazoles were designed and synthesized, paying particular attention to the reduction of their lipophilicity and to the improvement of the affinity towards the drug-resistant T315I mutant. Compound 5 was identified as a promising allosteric inhibitor of the T315I mutant.

ANTI-HIV COMPOUNDS

Thiazole derivatives represented by Formula (I) are disclosed, where R1, R2, R3, A, X, Y, Z, R6 and R7 are disclosed herein. These thiazole derivatives and pharmaceutical compositions comprising these derivatives are useful in the treatment of HIV mediated diseases and conditions.

Heterocyclic compounds and medical use thereof

The present invention provides an AP-1 activation inhibitor, a NF-kappaB activation inhibitor, an inflammatory cytokine production inhibitor, a production inhibitor for matrix metalloprotease or an inflammatory cell adhesion factor expression inhibitor, which contains a heterocyclic compound or a pharmaceutically acceptable salt thereof as an active ingredient.