31909-05-4

Basic information

• Product Name: 3-BENZO[B]THIOPHEN-2-YL-PROPAN-1-OL
• Synonyms: 3-BENZO[B]THIOPHEN-2-YL-PROPAN-1-OL
• CAS NO: 31909-05-4
• Molecular Formula: C11H12OS
• Molecular Weight: 192.28
• Mol File: 31909-05-4.mol

Chemical Properties

• Boiling Point: 349.8±17.0 °C(Predicted)
• Appearance: /
• Density: 1.202±0.06 g/cm3(Predicted)
• PKA: 14.99±0.10(Predicted)
• CAS DataBase Reference: 3-BENZO[B]THIOPHEN-2-YL-PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BENZO[B]THIOPHEN-2-YL-PROPAN-1-OL(31909-05-4)
• EPA Substance Registry System: 3-BENZO[B]THIOPHEN-2-YL-PROPAN-1-OL(31909-05-4)

Safety Data

• Hazardous Substances Data: 31909-05-4(Hazardous Substances Data)

Upstream product

• 750638-28-9 3-(benzo[b]thiophen-2-yl)-2-propyn-1-ol 
• 42768-60-5 3-(benzothiophene-2-yl)propanoic acid 
• 65942-76-9 C₁₂H₁₂O₂S 

Downstream Products

• 1206488-76-7 3-(benzo[b]thiophen-2-yl)-1-propyl 4-methylbenzenesulfonate 

Relevant articles and documents

AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF

Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.

Regioselective synthesis of heterocycles containing nitrogen neighboring an aromatic ring by reductive ring expansion using diisobutylaluminum hydride and studies on the reaction mechanism

(Chemical Equation Presented) A systematic investigation of the reductive ring-expansion reaction of cyclic ketoximes fused to aromatic ringswith diisobutylaluminum hydride (DIBALH) is described. This reaction regioselectively afforded a variety of five- to eight-membered bicyclic heterocycles or tricyclic heterocycles containing nitrogen neighboring an aromatic ring, including indoline, 1,2,3,4,5,6-hexahydrobenz[b]azocine, 3,4-dihydro-2H-benzo[b] [1,4]oxazine, 2,3,4,5-tetrahydrobenzo[b][1,4]thiazepine, 1,2,3,4,5,6- hexahydroazepino[3,2-b]-indole, 2,3,4,5-tetrahydro-1H-benzothieno[2,3-b]azepine, 2,3,4,5-tetrahydro-1H-benzothieno[3,2-b]-azepine, 5,6-dihydrophenanthridine, and 5,6,11,12-tetrahydrodibenz[b, f]azocine. The reaction mechanism leading to the rearrangement was investigated on the basis of the restricted Becke three-parameter plus Lee-Yang-Parr (B3LYP) density functional theory (DFT) with the 6-31G (d) basis set. It was found that the reaction proceeds through a three-centered transition state via a stepwise mechanism because the potential energy curve along the intrinsic reaction coordinate (IRC) had twomaxima (saddle points; TS1 and TS2) and the partial phenonium cation intermediate C. In addition to cyclic ketoximes fused to aromatic rings, the reactions of various cyclic and acyclic ketoximeswere examined to investigate preference of migrating group. It was found that themore electron-rich group migrated preferentially to give the corresponding secondary amines.

1-AZA-BICYCLO [2.2.2] OCTANE DERIVATIVES USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS

The invention provides named compounds of formula (I), pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions and their use in therapy.

2,3,4-substituted cyclopentanones as therapeutic agents

Disclosed herein are compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof; wherein Y, A, B, J, and E are further described. Methods, compositions, and medicaments related thereto are also disclosed.