319442-16-5

Basic information

• Product Name: Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl-
• Synonyms: Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl-
• CAS NO: 319442-16-5
• Molecular Formula: C₇H₅ClN₂S
• Molecular Weight: 184.646
• EINECS: 200-589-5
• Mol File: 319442-16-5.mol

Chemical Properties

• Boiling Point: 208℃
• Flash Point: 80℃
• Appearance: /
• Density: 1.445
• Refractive Index: 1.682
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.99±0.40(Predicted)
• CAS DataBase Reference: Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl-(319442-16-5)
• EPA Substance Registry System: Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl-(319442-16-5)

Safety Data

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45
• WGK Germany: 3
• Hazardous Substances Data: 319442-16-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Thieno[3,2-d]pyrimidine, 4-chloro-2-methylis used as a building block for the synthesis of various drugs and bioactive molecules. Its unique structure and functional groups make it a valuable component in the development of new therapeutic agents.
Used in Medicinal Chemistry:
Thieno[3,2-d]pyrimidine, 4-chloro-2-methylis studied for its potential pharmacological properties, including anti-cancer and anti-inflammatory activities. Its ability to modulate biological pathways and target specific receptors makes it a promising candidate for the treatment of various diseases.
Used in Drug Discovery:
As a versatile compound, Thieno[3,2-d]pyrimidine, 4-chloro-2-methylplays a crucial role in drug discovery. Researchers utilize its chemical properties to design and optimize new drug candidates, aiming to improve their efficacy, selectivity, and safety profiles. Thieno[3,2-d]pyrimidine, 4-chloro-2-methylserves as a valuable tool in the ongoing quest to develop innovative therapeutics for unmet medical needs.

InChI:InChI=1/C7H5ClN2S/c1-4-9-5-2-3-11-6(5)7(8)10-4/h2-3H,1H3

Upstream product

• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 22288-79-5 3-acetylamine-2-thiophenecarboxylic acid methyl ester 
• 1037297-94-1 3-acetamidothiophene-2-carboxamide 
• 147123-47-5 3-aminothiophene-2-carboxamide 
• 1611471-26-1 ethyl 3-amino-2-thiophene-2-carboxylate hydrochloride 
• 18678-13-2 2-methyl-3H-thieno[3,2-d]pyrimidin-4-one 
• 18678-13-2 2-methylthieno[3,2-d]pyrimidin-4-ol 

Downstream Products

• 936837-05-7 N-(4-methoxyphenyl)-N,2-dimethylthieno[3,2-d]pyrimidin-4-amine 
• 935843-00-8 N-(2,5-dimethoxyphenyl)-2-methylthieno[3,2-d]pyrimidin-4-amine 

Relevant articles and documents

Thienopyrimidine derivative as an active ingredient a plant disease control agent (by machine translation)

[Problem] in plant disease resistance-inducing gene expression found thienopyrimidine derivative effect, utilizing the thienopyrimidine derivatives, injuries to plant disease organisms[Solution] some of the thienopyrimidine derivatives, such as gene expression in a plant disease-resistance gene to induce PR-a 1, therefore cruciferous vegetables against plant diseases caused by pathogenic bacillus anthracis, exhibiting excellent control effect was found. [Drawing] no (by machine translation)

MONOCYCLIC, THIENO, PYRIDO, AND PYRROLO PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE OF THE SAME

The present invention provides monocyclic, thieno, pyrido and pyrrolo pyrimidine compounds. Pharmaceutical compositions comprising one or more of these compounds and optionally comprising a pharmaceutically acceptable salt or hydrate of one or more of the compounds are provided. Preferably, these pharmaceutical compositions further comprise at least one pharmaceutically acceptable carrier. Methods of treating a patient having cancer are provided wherein a therapeutically effective amount of one or more of these compounds or pharmaceutical compositions are administered to the patient.

Discovery of new hit-molecules targeting Plasmodium falciparum through a global SAR study of the 4-substituted-2-trichloromethylquinazoline antiplasmodial scaffold

From 4 antiplasmodial hit-molecules identified in 2-trichloromethylquinazoline series, we conducted a global Structure-Activity relationship (SAR) study involving 26 compounds and covering 5 molecular regions (I – V), aiming at defining the corresponding

Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold

A series of novel thienopyrimidin-4-amines have been synthesized and evaluated as phosphodiesterase (PDE) inhibitors. A rationale for the observed selectivity against PDE7 has been obtained from molecular modelling studies on the most active compounds. This journal is the Partner Organisations 2014.

THIENO[3,2-D]PYRIMIDINE-6-CARBOXAMIDES AND ANALOGUES AS SIRTUIN MODULATORS

Provided herein are novel substituted thieno[3,2-d]pyrimidine-6-carboxamide sirtuin inhibitors and methods of use thereof. The sirtuin inhibitors may be used for inhibiting a sirtuin-mediated biological process, and, e.g. for treating and/or preventing diseases and disorders including, but not limited to cancer, neurodegenerative disease and inflammation. Also provided herein are pharmaceutical compositions comprising these sirtuin inhibitors and compositions comprising a sirtuin inhibitor in combination with another therapeutic agent.

Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives

The (-)-(11R,2′S)-enantiomer of the antimalarial drug mefloquine has been found to be a reasonably potent and moderately selective adenosine A2A receptor antagonist. Further investigation of this compound has led to the discovery of a series of keto-aryl thieno[3,2-d]pyrimidine derivatives, which are potent and selective antagonists of the adenosine A2A receptor. These derivatives show selectivity against the A1 receptor. Furthermore, some of these compounds have been shown to have in vivo activity in a commonly used model, suggesting the potential for the treatment of Parkinson's disease.

N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof

Disclosed are N-aryl-thienopyrimidin-4-amines and analogs thereof, represented by the Formulae I-II: wherein Ar and R1-R4 are defined herein. The present invention relates to the discovery that compounds having Formulae I-II are acti

N-ALKYL-N-ARYL-THIENOPYRIMIDIN-4-AMINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF

Disclosed are N-alkyl-N-aryl-thienopyrimidin-4-amines and analogs thereof, represented by the Formulae I-II: wherein Ar, R1 -R4 and R10 are defined herein. The present invention relates to the discovery that compounds havi

Thieno-and furopyrimidine derivatives as A2A-receptor antagonists

Compounds of formula (I): wherein X is S. Compounds can be used for treating a disorder in which the blocking of purine receptors is beneficial.