320343-60-0 Usage
Uses
Used in Pharmaceutical Research:
(R)-(+)-1-BOC-4-HYDROXY-2-PYRROLIDINONE is used as a building block for the preparation of various biologically active compounds and pharmaceutical intermediates. Its chiral nature allows for the synthesis of enantiomerically pure molecules, which is essential for the development of effective and selective drugs.
Used in Organic Synthesis:
In the field of organic synthesis, (R)-(+)-1-BOC-4-HYDROXY-2-PYRROLIDINONE is utilized as a versatile starting material for the synthesis of complex organic molecules. The BOC protecting group enables selective reactions, while the hydroxy group offers a handle for further derivatization, making it a valuable component in the creation of diverse chemical structures.
Used in Asymmetric Synthesis:
(R)-(+)-1-BOC-4-HYDROXY-2-PYRROLIDINONE is employed as an important tool in asymmetric synthesis, where the stereochemistry of the compound is crucial for the production of enantiomerically pure molecules. This is particularly relevant in the development of pharmaceuticals, where the desired biological activity is often associated with a specific enantiomer.
Used in the Synthesis of Chiral Auxiliaries and Ligands:
Due to its chiral nature and functional groups, (R)-(+)-1-BOC-4-HYDROXY-2-PYRROLIDINONE can be used in the synthesis of chiral auxiliaries and ligands, which are essential in various asymmetric catalytic reactions. These auxiliaries and ligands can enhance the selectivity and efficiency of catalytic processes, leading to the production of enantiomerically pure compounds with high yields.
Check Digit Verification of cas no
The CAS Registry Mumber 320343-60-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,0,3,4 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 320343-60:
(8*3)+(7*2)+(6*0)+(5*3)+(4*4)+(3*3)+(2*6)+(1*0)=90
90 % 10 = 0
So 320343-60-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H15NO4/c1-9(2,3)14-8(13)10-5-6(11)4-7(10)12/h6,11H,4-5H2,1-3H3/t6-/m1/s1
320343-60-0Relevant articles and documents
Synthesis of nature product kinsenoside analogues with anti-inflammatory activity
Song, Wei,Sun, Yong,Xu, Lintao,Sun, Yajing,Li, Tianlu,Peng, Peng,Lou, Hongxiang
supporting information, (2020/12/02)
Kinsenoside is the major bioactive component from herbal medicine with a broad range of pharmacological functions. Goodyeroside A, an epimer of kinsenoside, remains less explored. In this report we chemically synthesized kinsenoside, goodyeroside A and their analogues with glycan variation, chirality inversion at chiral center(s), and bioisosteric replacement of lactone with lactam. Among these compounds, goodyeroside A and its mannosyl counterpart demonstrated superior anti-inflammatory efficacy. Furthermore, goodyeroside A was found to suppresses inflammatory through inhibiting NF-κB signal pathway, effectively. Structure-activity relationship is also explored for further development of more promising kinsenoside analogues as drug candidates.
First total synthesis of a new pyrrolizidine alkaloid, amphorogynine A
Yoda, Hidemi,Egawa, Takahisa,Takabe, Kunihiko
, p. 1643 - 1646 (2007/10/03)
An efficient and stereodefined strategy is described for the first asymmetric synthesis of a new type of pyrrolizidine alkaloids, amphorogynine A and its 1-epi-isomer. The key 2,4-disubstituted pyrrolidine ring was constructed by elaboration of the chiral
Preparation of (S)-N-Substituted 4-Hydroxy-pyrrolidin-2-ones by Regio- and Stereoselective Hydroxylation with Sphingomonas sp. HXN-200
Chang, Dongliang,Witholt, Bernard,Li, Zhi
, p. 3949 - 3952 (2007/10/03)
formula presented Enantiopure (S)-N-substituted 4-hydroxy-pyrrolidin-2-ones have been prepared for the first time by regio- and stereoselective hydroxylation of the corresponding pyrrolidin-2-ones by use of a biocatalyst. Hydroxylation of 6 and 8 with Sph
